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ProteomicsB. abortus 104M LC-MS/MS - A comprehensive proteogenomic study of the human Brucella vaccine strain 104 M
In the present study, we performed subcellular fractionation prior to protein extraction to reduce interference. Whole cell protein and membrane protein extracts were prepared for strain 104M. Peptide fractionation prior to analysis is an alternative method that achieves higher proteome coverage. Co...
ORGANISM(S): Brucella abortus 104M 
2017-05-29 | PXD005403 | Pride
B. abortus 104m Lc-ms/ms 
TranscriptomicsRNA-seq data sets of human non small cell lung cancer line A549 treated with feiyanning against untreated controls, during co-culture with macrophages.
RNA-seq analysis was performed in co-cultured A549 cells with or without feiyanning. A549 cells and macrophages were incubated 48h together in serum-free medium for producing co-cultured A549 cells. Treated groups were supplemented with Chinese traditional medicine Feiyanning.
ORGANISM(S): Homo sapiens 
2023-12-31 | E-MTAB-12420 | biostudies-arrayexpress
TranscriptomicsNUDT21 Negatively Regulates PSMB2 and CXXC5 by Alternative Polyadenylation and Contributes to Hepatocellular Carcinoma Suppression
HCC is the third leading cause of cancer-related deaths worldwide. However, the molecular mechanisms underlying the progression of HCC is still largely elusive. NUDT21 (CFIm25) is an important mediator of 3′ UTR APA and demonstrates a causal relationship between alternative polyadenylation and cance...
ORGANISM(S): Homo sapiens 
2018-01-25 | E-MTAB-6368 | biostudies-arrayexpress
ProteomicsPinctada fucata martensii shell matrix protein LC-MSMS
Nacre, the iridescent material found in pearls and shells of molluscs, is formed through an extraordinary process of matrix-assisted biomineralization. Despite recent advances, many parts of the biomineralization process and its evolutionary origin remain a mystery. The pearl oyster Pinctada fucata ...
ORGANISM(S): Bivalvia 
2017-07-07 | PXD006786 | Pride
Lc-msms Shell matrix protein Pearl oyster 
MetabolomicsAltered metabolome and microbiome features provide clues in understanding irritable bowel syndrome and depression comorbidity

Irritable bowel syndrome (IBS) is one of the functional gastrointestinal disorders characterized by chronic and/or recurrent symptoms of abdominal pain and irregular defecation. Changed gut microbiota has been proposed to mediate IBS; however, contradictory results exist, and IBS-specific microbi...

2021-12-01 | MTBLS2774 | MetaboLights
ProteomicsHOXB13 WT and G84E mass spectrometry
To identify potential cofactors of HOXB13 in suppressing lipogenic programs in prostate cancer cells, we performed tandem affinity purification followed by mass spectrometry analysis of WT and G84E HOXB13 expressed in LNCaP cells. Out of the HOXB13-enriched proteins are previously reported interacto...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD030810 | Pride
Prostate cancer Tandem affinity purification Hoxb13 
ProteomicsHAT1-meidated phosphoproteomics liver tissues
Phosphoproteomics in liver tissues of WT and Hat1-/-mice
ORGANISM(S): Mus Musculus 
PXD043633 |
TranscriptomicsHypoxia transcriptome sequencing of blind mole rat (BMR, Spalax galili) and rat (Rattus norvegicus)
Deep sequencing of mRNA from Spalax galili and Rattus norvegicus Total RNAs were isolated from the brain of female BMRs under various oxygen concentrations (3%, 6%, 10%, 14%, and 21%) for 6 hours. We also got RNAs from the brain of rats under 6%, 10%, 14%, and 21% oxygen conditions.
ORGANISM(S): Nannospalax galili 
2014-06-05 | E-GEOD-49485 | biostudies-arrayexpress
ProteomicsIdentify FOXA2-interacting proteins in NEPC cells
Following extensive treatment with androgen receptor (AR) pathway inhibitors, a significant number of metastatic prostate cancer develop treatment resistance, and approximately 20% of these castration-resistant prostate cancers (CRPC) transdifferentiate, at least partially, into neuroendocrine (NE) ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-12 | PXD061080 | Pride
Nepc Foxa2 
ProteomicsIdentify FOXA2-interacting proteins in NEPC cells
Following extensive treatment with androgen receptor (AR) pathway inhibitors, a significant number of metastatic prostate cancer develop treatment resistance, and approximately 20% of these castration-resistant prostate cancers (CRPC) transdifferentiate, at least partially, into neuroendocrine (NE) ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-12 | PXD061127 | Pride
Nepc Foxa2 
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