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Human fetal γ-globin gene is developmentally silenced around the birth, and reactivation of γ-globin gene in adulthood sheds new light on ameliorating symptoms of hemoglobin disorders, such as sickle cell disease (SCD) and β-thalassemias. However, the precise regulation process of γ-globin remains i...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD024259 | Pride
Post-transcriptional Regulation Maintains Neurogenic Potential of Human Neural Progenitor Cells
Caffeic acid phenethyl ester (CAPE), derived from various plant sources, has been shown to ameliorate ischemia/reperfusion (I/R) injury in vivo, and this has been attributed to its ability to reduce the oxidative stress. Here we investigated the cytoprotection of CAPE against menadione (MD)-induced ...
ORGANISM(S): Homo sapiens 
Caffeic acid phenethyl ester (CAPE), derived from various plant sources, has been shown to ameliorate ischemia/reperfusion (I/R) injury in vivo, and this has been attributed to its ability to reduce the oxidative stress. Here we investigated the cytoprotection of CAPE against menadione (MD)-induced ...
ORGANISM(S): Homo sapiens 
This SuperSeries is composed of the following subset Series: GSE10413: Gene expression profiling of caffeic acid phenethyl ester-treated human umbilical vein endothelial cells-1 GSE10429: Gene expression profiling of caffeic acid phenethyl ester -treated human umbilical vein endothelial cells-2 Keyw...
ORGANISM(S): Homo sapiens 
Rett syndrome (RTT) is a devastating neurodevelopmental disorder that occurs once in every 10,000-15,000 live female births. Despite intensive research, no effective cure is yet available. Valproic acid (VPA) has been used widely to treat mood disorder, epilepsy, and a growing number of other disord...
ORGANISM(S): Mus musculus 
Nanoparticle rigidity influences cellular uptake and in vivo behavior, yet the underlying mechanisms remain unclear. Here, we used lipids with identical head groups but different alkyl chains to prepare liposomes with comparable surface composition, size and zeta potential, but distinct mechanical p...
ORGANISM(S): Bos taurus (Bovine) 
2026-10-05 | PXD079018 | Pride
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