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ProteomicsSecretome profiling of Cryptosporidium sporozoites in the initial interaction processes with host epithelial cells
Sporozoites secrete proteins which can help them adhere to/invade host cells during gliding motility on the surface of host cells. Currently, the composition of secreted proteins of C. parvum during adhesion/invasion of host cells is not fully understood. In this study, TMT labeled quantitative prot...
ORGANISM(S): Homo sapiens (Human) Limnobaculum parvum 
2025-11-17 | PXD028969 | Pride
Secrete proteins Cryptospordium Sporozoites 
ProteomicsZSWIM4 regulates early embryonic patterning and BMP signaling pathway by promoting nuclear Smad1 degradation
The dorsoventral gradient of BMP signaling plays an essential role in embryonic patterning, with high BMP signal activating ventral-lateral mesoderm markers directly, and low BMP signal inducing neural tissues. The Zinc finger SWIM domain-containing protein 4 (zswim4) is expressed in the dorsal blas...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD035207 | Pride
Zswim4 Bmp Smad1 
UnknownSemenogelin I-derived peptide SgI-52 binds membrane Peroxiredoxin 6 and induces oxidative stress in asthenozoospermic sperm.
Not available
S-EPMC12853945 | biostudies-literature
ProteomicsProteomic Profiling and Functional Analysis of B Cell-Derived Exosomes upon Pneumocystis Infection
Pneumocystis is a life-threatening fungal pathogen frequently causing fatal pneumonia (PCP) in immunocompromised individuals with high mortality. Recently, B cells have been reported to play a crucial role in the pathogenesis of PCP through producing antibodies and activating CD4+ T cell response. E...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-26 | PXD030103 | Pride
Exosomes Mass spectrometry B lymphocytes Pneumocystis pneumonia 
UnknownlncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/β-catenin signaling.
Not available
S-EPMC6961326 | biostudies-literature
UnknownEchocardiographic assessment of Xenopus tropicalis heart regeneration.
Not available
S-EPMC9926761 | biostudies-literature
Proteomics,Multiomicsembryo_proteome
We collected over 8000 mouse embryos of each developmental stage (zygote, 2-cell, 4-cell, 8-cell, morula, blastocyst) and performed tandem mass tag (TMT)-based quantitative mass spectrometry and identified nearly 5000 proteins for each stage. In-depth analysis indicates that protein expression profi...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2015-12-10 | MSV000079417 | MassIVE
UnknownZSWIM4 regulates embryonic patterning and BMP signaling by promoting nuclear Smad1 degradation.
Not available
S-EPMC10897318 | biostudies-literature
UnknownThe Proto-oncogene Transcription Factor Ets1 Regulates Neural Crest Development through Histone Deacetylase 1 to Mediate Output of Bone Morphogenetic Protein Signaling.
Not available
S-EPMC4571947 | biostudies-literature
UnknownMiR-30a Inhibits the Epithelial--Mesenchymal Transition of Podocytes through Downregulation of NFATc3.
Not available
S-EPMC4632736 | biostudies-literature
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