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ProteomicsEGFR-TKI-down-regulated proteins in HCC827 cells
EGFR mediates stabilities of a wide spectrum of proteins. Treatment of the cells with EGFR tyrosine kinase inhibitors (EGFR-TKIs) leads to degradation of these proteins. To define the proteins and corresponding pathways of EGFR-stabilized proteins, we use mass spectrum to quantify the protein level...
ORGANISM(S): Homo sapiens (Human) 
2025-05-13 | PXD050420 | Pride
Human egfr mutated lung cancer cells 
TranscriptomicsComparison of DNA methylation profiles in diploid and transformed tetraploid MEF cells
We propose that tetraploidy induces epigentic changes including DNA methylation due to the abnormal chromatin in the cells. To test our hypothesis, we employed methylated CpG island recovery assay (MIRA) assisted microarray to determine the DNA methylation profiles in both diploid and tetraploid cel...
ORGANISM(S): Mus musculus 
2012-04-29 | E-GEOD-18814 | biostudies-arrayexpress
ProteomicsDNA2 and MSH2 activities collectively mediate environmental chemical compound stabilized G4 for efficient telomere replication
G-quadruplexes (G4s) are widely existing stable DNA secondary structures in mammalian cells. A long-standing hypothesis is that timely resolution of G4s is needed for efficient and faithful DNA replication. In vitro, G4s may be unwound by helicases or alternatively resolved via DNA2 nuclease-mediate...
ORGANISM(S): Homo sapiens (Human) 
2025-08-07 | PXD059843 | Pride
G-quadruplex Msh2 Dna2 Telomere 
TranscriptomicsComparison of gene expression profiles in diploid and transformed tetraploid MEF cells
We propose that abnormal DNA content in tetraploid cells can alter the gene expression profile, contributing to the cellular transformation. To test this hypothesis, we employ mRNA microarray to compare the gene expression profile in transformed tetraploid cells with that in the parent diploid cells...
ORGANISM(S): Mus musculus 
2012-04-29 | E-GEOD-18802 | biostudies-arrayexpress
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