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ProteomicsFunctional insights into protein acetylation in the hyperthermophilic archaeon Sulfolobus islandicus
Proteins undergo acetylation at the Nε-amino group of lysine residues and the Nα-amino group of the N-terminus in Archaea as in Bacteria and Eukarya. However, the extent, pattern and roles of the modifications in Archaea remain poorly understood. Here we report the proteomic analyses of a wild-type ...
ORGANISM(S): Sulfolobus islandicus REY15A 
2019-06-12 | PXD012246 | Pride
Quantitative proteomics Protein acetylome Gene deletion Mutant phenotype N-terminal acetyltransferase Protein lysine acetyltransferase 
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
ProteomicsProtein modification by a eukaryotic-like ubiquitin-related modifier in the hyperthermophilic archaeon Saccharolobus islandicus
Three independent analyses of Urm1 conjugation sites in the proteome of S. islandicus urm1 H81R strain were conducted. The data were analyzed using MaxQuant (v.1.6.15.0), and modified peptides were identified using a stringent standard.
ORGANISM(S): Sulfolobus islandicus REY15A 
2025-08-21 | PXD057602 | Pride
Saccharolobus islandicus Knockdown Urm1 Substrate 
ProteomicsOne Brucella proteins solution sample, complete protein and 5 modifications Label-free omics research (No duplication,F8097WB remaining protein) analysis report.
Considering the role of PTMs(2-hydroxyisobutyrylation, succinylation, crotonylation, acetylation, and malonylation) in various biological processes of Brucella virulence and survival, we propose that the virulence of Brucella is associated with the PTMs of proteins. Taken together, this study provid...
ORGANISM(S): Brucella abortus (strain 2308) 
2022-03-04 | PXD030621 | Pride
Brucella 2308 lc-msms 
UnknownPyrotinib and chrysin synergistically potentiate autophagy in HER2-positive breast cancer.
Not available
S-EPMC10728098 | biostudies-literature
ProteomicsGPX4 immunoprecipitation in Huh7 cells
Huh7 cells with expression of Flag-GPX4 were treated with IGF1. An immunoprecipitation assay was performed, and immunoprecipitates were subjected to masspec analysis.
ORGANISM(S): Human 
2023-02-22 | MSV000091343 | MassIVE
UnknownExploratory phase II trial of an anti-PD-1 antibody camrelizumab combined with a VEGFR-2 inhibitor apatinib and chemotherapy as a neoadjuvant therapy for triple-negative breast cancer (NeoPanDa03): efficacy, safety and biomarker analysis.
Not available
S-EPMC12279984 | biostudies-literature
ProteomicsPPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1
Our study have shown that PPDPF promoted NF-κB activation through TRIM21-mediated K63-linked ubiquitination of RIPK1 in hepatocytes. Upon TNF-α stimulation, PPDPF enhances TRIM21/RIPK1 interaction and increases TRIM21-mediated K63-linked ubiquitination of RIPK1, which promotes NF-κB activation.To ma...
ORGANISM(S): Homo Sapiens 
2023-02-21 | PXD040301 |
ProteomicsGel-based LC-MSMS, the interactome of XAF1 in 293T cells
We utilized mass spectrometry to analyze the interacting proteins of XAF1 in 293T cells.
ORGANISM(S): Homo Sapiens 
2023-03-22 | PXD041021 |
ProteomicsIntegrated Proteomics and Metabolomics Analysis in Pregnant Rat Hippocampus After Circadian Rhythm Inversion
To investigate the changes in proteins, metabolites, and related mechanisms in the Q7 hypothalamus of pregnant rats after circadian rhythm inversion during the whole pregnancy cycle
ORGANISM(S): Rattus Rattus 
2022-06-26 | PXD034926 |
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