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ProteomicsCharacterization of SGK3-PROTAC1, a highly specific SGK3 kinase PROTAC degrader
SGK3 is a PX domain containing protein kinase activated at endosomes downstream of Class 1 and 3 PI3K family members by growth factors and oncogenic mutations. SGK3 plays a key role in mediating resistance of breast cancer to Class 1 PI3K or Akt inhibitors, by substituting for loss of Akt and restor...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD013779 | Pride
Protac Sgk3 Degradation 
ProteomicsModulating the selectivity of affinity absorbents to multi-phosphopeptides by a novel competitive substitution strategy
Although many affinity adsorbents have been developed for phosphopeptides enrichment, high-specifically capturing the multi-phosphopeptides is still a big challenge. Here, we investigated the mechanism of phosphate ions coordination and substitution on affinity adsorbents surfaces and modulated the ...
ORGANISM(S): Homo sapiens (Human) 
2016-08-03 | PXD004252 | Pride
Mass spectrometry Multi-phosphopeptide enrichment Pre-coordination Phosphoproteomics Competitive substitution 
ProteomicsRapid and reversible knockdown of endogenously tagged endosomal proteins via an optimized HaloPROTAC degrader
Combining pharmacologic and genetic tools to induce post-translational protein knockdown is an emerging approach to probe biology and validate potential drug targets. A powerful strategy involves expression of a protein of interest fused to an exogenous tag, allowing tag-directed chemical degraders ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-13 | PXD012828 | Pride
Haloprotac Vps34 Degradation 
ProteomicsThe FGF4-dependent phosphoproteome in mouse embryonic stem cells
Protein kinase signalling is a major mechanism by which embryonic stem cell pluripotency and differentiation is controlled. However, the pathways and components that regulate embryonic stem cell identity have not been systematically defined. Here, we employ FGF4 signalling as a model system to inves...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-24 | PXD012069 | Pride
Kinase Phosphorylation Growth factor Mouse embryonic stem cell 
ProteomicsHs_K562_Ti-IMAC_1D_FTETD
Hs_K562_Ti-IMAC_1D_FTETD
ORGANISM(S): Homo Sapiens (human) 
2013-12-31 | PAe005248 | PeptideAtlas
ProteomicsHs_Hela-Ti-IMAC_1D_FTETD
Hs_Hela-Ti-IMAC_1D_FTETD
ORGANISM(S): Homo Sapiens (human) 
2013-12-31 | PAe005295 | PeptideAtlas
ProteomicsHs_Hela-Ti-IMAC-HILIC_2D_FTETD
Hs_Hela-Ti-IMAC-HILIC_2D_FTETD
ORGANISM(S): Homo Sapiens (human) 
2013-12-31 | PAe005292 | PeptideAtlas
ProteomicsHs_Hela-Ti-IMAC-HILIC_3D_FTETD
Hs_Hela-SCX-Ti-IMAC-HILIC_3D_FTETD
ORGANISM(S): Homo Sapiens (human) 
2013-12-31 | PAe005290 | PeptideAtlas
ProteomicsHs_K562-Ti-IMAC-HILIC_3D_FTETD
Hs_K562_SCX-Ti-IMAC-HILIC_3D_FTETD
ORGANISM(S): Homo Sapiens (human) 
2013-12-31 | PAe005288 | PeptideAtlas
ProteomicsHs_Hela-Ti-IMAC-HILIC_2D_ITETD
Hs_Hela-Ti-IMAC-HILIC_2D_ITETD
ORGANISM(S): Homo Sapiens (human) 
2013-12-31 | PAe005286 | PeptideAtlas
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