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ProteomicsIdentification of novel KRT32-associated proteins in primary keratinocytes cells lysate by GST-KRT32 pulldown assays coupled with mass spectrometry.
GST-KRT32 and its interacting proteins in primary keratinocytes cells were enriched by pull-down using glutathione-Sepharose beads. Then, KRT32-interacting proteins were identified by mass spectrum. Proteins obtained in Pulldown were subjected to SDS-PAGE gel electrophoresis and silver staining. The...
ORGANISM(S): Homo sapiens (Human) 
2024-06-17 | PXD050141 | Pride
Keratin  krt32 
ProteomicsHK-2 cells 4D label quantitative lactylproteomic analysis
Following acute kidney injury (AKI), a substantial subset of patients experiences an irreversible progression to chronic kidney disease (CKD), yet the molecular determinants governing this maladaptive transition remain elusive, and effective clinical interventions are lacking. Here, we identify lact...
ORGANISM(S): Homo sapiens (Human) 
2026-07-18 | PXD078736 | Pride
Human  lactylation 
UnknownComparative Proteomic Analysis of Lysine Acetylation in Fish CIK Cells Infected with Aquareovirus.
Not available
S-EPMC5713387 | biostudies-literature
ProteomicsKu80 lysine crotonylation conversion to SUMOylation facilitates DNA non-homologous end joining and cellular resistance to radiation
A DNA double-strand break (DSB) is the most serious DNA damage and is also the principal molecular basis of radiotherapy. Upon DNA damage, the Ku80 is recruited and forms a critical DNA-PK complex at the DSB sites with Ku70 and the catalytic subunit (DNA-PKcs) to initiate DNA repair. How DNA-PK is a...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD061039 | Pride
Dna double-strand break repair  ku80  crotonylation  sumoylation  dna-pk holoenzyme assembly  radioresistance 
Proteomicsβ-catenin-controlled tubular cell-derived exosomes play a key role in fibroblast activation via the OPN-CD44 axis
Tubular injury and peripheral fibroblast activation are the hallmarks of chronic kidney disease (CKD) and renal fibrosis, suggesting intimate communication between the two diseases. However, the underlying mechanisms remain to be determined. Exosomes play a role in shuttling proteins and other mater...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030696 | Pride
Opn Cd44 Exosomes Β-catenin Renal fibrosis 
UnknownQuantitative Succinyl-Proteome Profiling of Camellia sinensis cv. 'Anji Baicha' During Periodic Albinism.
Not available
S-EPMC5431936 | biostudies-literature
ProteomicsAsp23-controlled cell wall imbalance promotes membrane vesicles biogenesis in Staphylococcus aureus
Membrane vesicles (MVs) are produced by species across all domains of life and have diverse physiological functions and promising applications. While the mechanisms for vesiculation in Gram-negative bacteria are well-established, the genetic determinant and regulation of MVs biogenesis in Gram-posit...
ORGANISM(S): Staphylococcus aureus (strain Newman) 
2024-01-10 | PXD048184 | Pride
Membrane vesicles  staphylococcus aureus  sigb  asp23  proteomic analysis 
UnknownMarek's Disease Virus Regulates the Ubiquitylome of Chicken CD4+ T Cells to Promote Tumorigenesis.
Not available
S-EPMC6539122 | biostudies-literature
ProteomicsJosephin Domain Containing 2 (JOSD2) Inhibition as Pan-KRAS-Mutation-Targeting Strategy for Colorectal Cancer
KRAS is the most common mutated oncogenes in colorectal cancer (CRC), yet effective therapeutic strategies for targeting multiple KRAS-mutations remained challenging. The prolonged protein stability of KRAS mutants contribute to their robust tumor-promoting effects, but the underlying mechanism is e...
ORGANISM(S): Homo sapiens (Human) 
2025-03-01 | PXD054525 | Pride
Deubiquitinases Ubiquitination. Josd2 Kras Colorectal cancer 
ProteomicsTMT-based quantitative proteomics analysis reveals the attenuated replication mechanism of Newcastle disease virus caused by nuclear localization signal mutation in viral matrix protein
Nuclear localization of cytoplasmic RNA virus proteins mediated by intrinsic nuclear localization signal (NLS) plays essential roles in successful virus replication. We previously reported that NLS mutation in the matrix (M) protein obviously attenuates the replication and pathogenicity of Newcastle...
ORGANISM(S): Cricetidae 
2020-05-22 | PXD018098 | Pride
Newcastle disease virus  matrix protein  nuclear localization signal  nucleocytoplasmic trafficking  tmt  quantitative proteomics 
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