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MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
ProteomicsU2OS osteosarcoma cells LC-MSMS
In order to identify the targets of miR-193a-5p in osteosarcoma U2OS cell line, we used a lentivirus-mediated expression system to overexpressing miR-193a precusor, miR-193a-5p target sequence and non-target sequence, respectively, in osteosarcoma cell line U2OS. A tandem mass tag (TMT)-based quanti...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD013987 | Pride
Lc-msms Osteosarcoma U2os Mir-193a-5p 
ProteomicsTime-resolved metabolomics and proteomics of Brassica napus guard cells under low CO2 concentration
In order to discover new nodes and edges for low CO2-induced stomata closure, we applied hyphenated mass spectrometry (MS)-based metabolomics and proteomics approaches to analyze short-term low CO2 responses in B. napus (canola) guard cells. A total of 411 metabolites were quantified. We observed de...
ORGANISM(S): Brassica napus (Rape) 
2018-10-26 | PXD005787 | Pride
Metabolomics Stomatal movement Carbon dioxide Phytohormones Proteomics Guard cell 
TranscriptomicsComparison of gene expression profiling of human lung at four developmental stages and lung adenocarcioma
It is gradually becoming a new aspect in research to search and explore embryo development for malignant information hidden in tumor cells. In this study, the gene expression profiles for human lungs at four developmental stages and lung adenocarcinoma (ADC) were depicted, respectively. The molecula...
ORGANISM(S): Homo sapiens 
2014-08-25 | E-GEOD-43767 | biostudies-arrayexpress
MetabolomicsEffect of Zanthoxylum bungeanum essential oil on rumen enzyme activity, microbiome, and metabolites in lambs

Antibiotics were once used in animal production to improve productivity and resistance to pathogenic microbiota. However, due to its negative effects, the search for a new class of substances that can replace its efficacy has become one of the urgent problems to be solved. Plant essential oils (E...

2022-09-13 | MTBLS3683 | MetaboLights
MetabolomicsSerum metabolomic profiles for distinguishing lung cancer from pulmonary tuberculosis: identification of rapid and noninvasive biomarker

BACKGROUND: Pulmonary tuberculosis (TB) and lung cancer (LC) have similar clinical symptoms and atypical imaging findings which are easily misdiagnosed. There is an urgent need for a noninvasive, rapid and accurate biomarker for distinguishing LC from TB.

METHODS:

2024-01-16 | MTBLS6990 | MetaboLights
UnknownIdentification of a 3-gene signature based on differentially expressed invasion genes related to cancer molecular subtypes to predict the prognosis of osteosarcoma patients.
Not available
S-EPMC8806416 | biostudies-literature
UnknownAstragaloside IV inhibits angiotensin II-induced atrial fibrosis and atrial fibrillation by SIRT1/PGC-1α/FNDC5 pathway.
Not available
S-EPMC11128467 | biostudies-literature
ProteomicsCholangiocarcinoma PDHA1 Succinylation Suppresses Macrophage Antigen Presentation via α-KG Accumulation
Cholangiocarcinoma, ranking as the second most prevalent primary hepatic malignancy following hepatocellular carcinoma, is distinguished by its aggressive invasiveness and grim prognosis. Over the past decade, chemotherapy has persisted as the standard first-line treatment for cholangiocarcinoma; Ho...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD060091 | Pride
Metabolism Pdha1 Macrophages Cholangiocarcinoma 
UnknownTranscriptome Differences in Response Mechanisms to Low-Nitrogen Stress in Two Wheat Varieties.
Not available
S-EPMC8622133 | biostudies-literature
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