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TranscriptomicsRNA-seq of mouse RAW264.7 macrophages treated with bone-metastatic lung cancer-derived exosomes to investigate osteoclast differentiation
This study aimed to elucidate the mechanism by which exosomes from bone-metastatic Lewis lung carcinoma (BM-LLC) cells promote osteolytic metastasis. We performed RNA-seq on mouse RAW264.7 macrophages (osteoclast precursors) treated with exosomes derived from either non-metastatic (NC-LLC) or bone-m...
ORGANISM(S): Mus musculus 
2025-12-31 | E-MTAB-15762 | biostudies-arrayexpress
MetabolomicsResearch on the quality markers of antioxidant activity of Kai-Xin-San based on spectrum-effect relationship
Kai-Xin-San (KXS) is one of the classic famous traditional Chinese medicine prescriptions for amnesia, which has been applied for thousands of years. Modern pharmacological research has found that KXS has significant therapeutic efficacy on nervous system diseases, which is related to its antioxidan...
2023-12-21 | MTBLS8806 | MetaboLights
MetabolomicsAltered metabolome and microbiome features provide clues in understanding irritable bowel syndrome and depression comorbidity

Irritable bowel syndrome (IBS) is one of the functional gastrointestinal disorders characterized by chronic and/or recurrent symptoms of abdominal pain and irregular defecation. Changed gut microbiota has been proposed to mediate IBS; however, contradictory results exist, and IBS-specific microbi...

2021-12-01 | MTBLS2774 | MetaboLights
ProteomicsSCN Proteomic Study:electroacupuncture induced circadian control in Suprachiasmatic Nucleus
Recent reports highlight phosphorylation as a major role in the regulation of sleep-wake cycles, to a lesser extent, the phosphoproteome in Suprachiasmatic Nucleus (SCN) is not well understood. We use multiplex tandem mass tag (TMT) - labelling coupled with liquid chromatography-mass spectrometry (L...
ORGANISM(S): Mus Musculus 
2021-10-31 | PXD029450 |
TranscriptomicsA dysregulated Acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity
Acetylation of transcriptional regulators is normally dynamically regulated by nutrient status but is often persistently elevated in nutrient-excessive obesity conditions. We investigated the functional consequences of such aberrantly elevated acetylation of the nuclear receptor FXR as a model. Prot...
ORGANISM(S): Mus musculus 
2014-10-17 | E-GEOD-62414 | biostudies-arrayexpress
ProteomicsQuantitative proteomic analysis of experimental autoimmune encephalomyelitis mice implicates SUMOylation in multiple sclerosis
In this study, we performed quantitative proteomics utilizing a data-independent acquisition (DIA) strategy to investigate the proteome alteration in the brain and spinal cord tissues from mice with experimental autoimmune encephalomyelitis (EAE), a widely-used model for MS.
ORGANISM(S): Mus Musculus 
2024-03-20 | PXD050789 |
UnknownUltrabright ratiometric Raman-guided epilepsy surgery by intraoperatively visualizing proinflammatory microglia.
Not available
S-EPMC12208331 | biostudies-literature
ProteomicsNanoliposuction recycles senescent cell lipids for lubrication
This study aims to systematically profile membrane protein alterations associated with chondrocyte senescence, in order to identify surface markers specifically upregulated in aged cartilage. We established two in vitro models by treating primary chondrocytes with IL-1β or bleomycin, and one in vivo...
ORGANISM(S): Mus Musculus 
2025-06-10 | PXD064867 |
ProteomicsGlobal Profiling of RNA-Binding Protein Target Sites by LACE-seq
Proteomic analysis of Ago2-/- oocytes revealed that Ago2 interacted with endogenous small interfering RNAs (endo-siRNAs) to repress mRNA translation globally.
ORGANISM(S): Mus Musculus 
2021-05-07 | PXD025846 |
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