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ProteomicsGasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1-mucin pathway
Pancreatic ductal adenocarcinoma (PDAC) originates from normal pancreatic ducts where digestive juice is regularly produced. It remains unclear how PDAC can escape auto-digestion by digestive enzymes. Here we show that human PDAC tumor cells use gasdermin E (GSDME), a pore-forming protein upon caspa...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030879 | Pride
Gsdme，pancreatic ductal adenocarcinoma，ybx1 Mucin 
ProteomicsDifferences in proteins between normal and asthmatic mice and effects of knockout TL1A on asthmatic mice
Asthma, a heterogeneous disease, is characterized by chronic inflammation, epithelial–mesenchymal transformation (EMT), and airway remodeling. After immune system activation, macrophages, T cells, and other cells gather and secrete various factors, such as interleukin-1β, 4, 5, 10, 13, and TNF-a, wh...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-20 | PXD031079 | Pride
Asthma Tl1a Emt Ova Airway remodeling Tnf-a 
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