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TranscriptomicsExpression data (U133 Plus 2.0) from fibroblast like synoviocytes from patients with rheumatoid arthritis (RA-FLS) stimulated by TL1A
TNF-like ligand 1A (TL1A) is a member of TNF receptor superfamily and involved in the pathogenesis of autoimmune diseases by inducing apoptosis via intracellular death domain or promoting inflammation through the activation of NFM-NM-:B by binding to its specific receptor death receptor 3 (DR3). Mea...
ORGANISM(S): Homo sapiens 
2014-12-10 | E-GEOD-63995 | biostudies-arrayexpress
ProteomicsProteome of group 2 innate lymphoid cells (ILC2s) stimulated with IL33 and TL1A
We analyzed the total proteome of group 2 innate lymphoid cells (ILC2s) after different stimulation with interleukin-33 (IL-33), a cytokine playing a critical role in human asthma, and TL1A, a TNF-family cytokine also known to activate ILC2s. Upon combined stimulation with IL-33 plus TL1A, we show t...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-05 | PXD041987 | Pride
Tl1a Cytokine Il33 Group 2 innate lymphoid cells Ilc2 Whole cell lysate Allergic inflammation Type 2 response Proteome Alarmin 
ProteomicsDifferences in proteins between normal and asthmatic mice and effects of knockout TL1A on asthmatic mice
Asthma, a heterogeneous disease, is characterized by chronic inflammation, epithelial–mesenchymal transformation (EMT), and airway remodeling. After immune system activation, macrophages, T cells, and other cells gather and secrete various factors, such as interleukin-1β, 4, 5, 10, 13, and TNF-a, wh...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-20 | PXD031079 | Pride
Asthma Tl1a Emt Ova Airway remodeling Tnf-a 
UnknownIBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein.
Not available
S-EPMC2648040 | biostudies-literature
TranscriptomicsTranscriptional profile of TL1A transgenic mice
To assess the effect of different forms of TL1A within different organs of the mouse we generated 2 different transgenic mouse lines where TL1A was expressed under the control of the CD2 promoter. 2 forms of TL1A was used. Either WT TL1A, which led to over expression of both membrane bound and solub...
ORGANISM(S): Mus musculus 
2017-12-14 | GSE98492 | GEO
UnknownThe TL1A-DR3 Axis in Asthma: Membrane-Bound and Secreted TL1A Co-Determined the Development of Airway Remodeling.
Not available
S-EPMC8914606 | biostudies-literature
GenomicsTL1A is a central regulator of group 3 innate lymphoid cell function in colitis
TL1A is a central regulator of group 3 innate lymphoid cell function in colitis
PRJNA494250 | ENA
UnknownBiochemical and structural characterization of the human TL1A ectodomain.
Not available
S-EPMC2790920 | biostudies-literature
UnknownRole of TL1A in Inflammatory Autoimmune Diseases: A Comprehensive Review.
Not available
S-EPMC9329929 | biostudies-literature
UnknownInhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis.
Not available
S-EPMC4205266 | biostudies-literature
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