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Focal adhesion kinase (FAK) is required for the expression of pro-inflammatory genes that inhibit anti-tumour immunity. Here, we show a novel and crucial role for the dual-function cytokine IL33 in FAK-dependent immune evasion. Specifically, nuclear FAK is required for the expression of IL33, the ch...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-06 | PXD007698 | Pride
Background and aim: Recent studies reveal a critical role of tumor cell-released extracellular vesicles (EVs) in pancreatic cancer progression. Driver genes directing EV function, the EV-recipient cells, as well as their cellular response to EV uptake remain, however, to be identified. To address th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-12-06 | MSV000093583 | MassIVE
Transcriptional profile of IL33 & PD1-treated ILC2 from KPC tumor-bearing mice
Coding RNA expression of blood eosinophils from mepolizumab- or omalizumab-treated patients stimulated ex vivo with IL-33 for 6 hours and of directly processed non-stimulated blood eosinophils from the same samples (paired design)
ORGANISM(S): Homo sapiens 
Transcriptomic analysis (RNAseq) of tumour-exposed Tregs from IL33 genetical deficient mice
Fungal mycobiome drives IL33 secretion and type 2 immunity in pancreatic cancer
Fungal mycobiome drives IL33 secretion and type 2 immunity in pancreatic cancer
Transposition of native chromatin (ATACseq) of tumour-exposed Tregs from IL33 genetical deficient mice
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