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MetabolomicsMetabolomic Profiling of Mice Serum during Toxoplasmosis Progression Using Liquid Chromatography-Mass Spectrometry
Better understanding of the molecular changes associated with disease is essential for identifying new routes to improved therapeutics and diagnostic tests. The aim of this study was to investigate the dynamic changes in the metabolic profile of mouse sera during T. gondii infection. We carried out ...
2017-01-25 | MTBLS216 | MetaboLights
MetabolomicsGlobal Metabolomic Profiling of Mice Brains following Experimental Infection with the Cyst-Forming Toxoplasma gondii
The interplay between the Apicomplexan parasite Toxoplasma gondii and its host has been largely studied. However, molecular changes at the metabolic level in the host central nervous system and pathogenesis-associated metabolites during brain infection are largely unexplored. We used a global metabo...
2017-01-27 | MTBLS217 | MetaboLights
MetabolomicsLung Lipidomic Alterations in Beagle Dogs Infected with Toxocara canis

Toxocariasis, mainly caused by Toxocara canis, and to a lesser extent, Toxocara cati, is a neglected parasitic zoonosis. The mechanisms that underlie the changes in lipid metabolism of T. canis infection in Beagle dogs' lungs remain unclear. Lipidomics is a rapidly emer...

2023-08-21 | MTBLS5583 | MetaboLights
ProteomicsFirst Global Proteomic Analysis of Lysine Malonylation in Toxoplasma gondii
Lysine malonylation (Kmal) is a new posttranslational modification (PTM), which has been reported in several prokaryotic and eukaryotic species. Although Kmal can regulate many and diverse biological processes in various organisms, knowledge about this important PTM in the apicomplexan parasite Toxo...
ORGANISM(S): Toxoplasma gondii 
2020-05-27 | PXD015809 | Pride
Post-translational  modifications Toxoplasma gondii Malonylome Lysine malonylation 
ProteomicsLabel-free Quantitative Acetylomics Revealed Toxoplasma gondii Genotype-Specific Acetylome Signatures
Distinct genotypic and pathogenicity differences exist between strains of the opportunistic protozoan Toxoplasma gondii. The label-free quantitative acetylomics approach was applied to investigate the differences in the level of acetylation between RH strain, PRU strain and PYS strain of T. gondii. ...
ORGANISM(S): Toxoplasma 
2020-05-27 | PXD015031 | Pride
Toxoplasma gondii  genotype  tachyzoite  acetylation  label-free 
ProteomicsProteome differences between sporulated oocysts of ToxoDB#9 and Type II Toxoplasma gondii
Understanding of protein expression difference in the same stage of T.gondii among different genotypes will facilitate the elucidation of genotypic divergence among the T.gondii strains. A 4-plex iTRAQ (isobaric tag for relative and absolute quantitation) based LC-MS/MS approach was employed to surv...
ORGANISM(S): Toxoplasma gondii 
2018-10-26 | PXD005928 | Pride
Itraq  differentially expressed protein (dep) Oxoplasma gondii  sporulated oocyst  genotype 
ProteomicsBufffalo serum iTRAQ - Global serum proteomic changes in water buffaloes infected with Fasciola gigantica
Fasciola gigantica infects buffalo in Asian and African countries and causes significant economic losses. As a kind of zoonotic parasite disease, human infection has been reported and make fascioliasis patients suffer heavy abdominal pain, anemia and workforce loss. Fasciola can modulate host immune...
ORGANISM(S): Bos taurus (Bovine) 
2019-11-12 | PXD011576 | Pride
Serum Itraq Buffalo 
ProteomicsComparative Analysis Reveals Genotype-specific Lyisne Malonylation of Toxoplasma gondii
Toxoplasma gondii is a protozoan parasite which can infect a wide range of animals, including humans. According to virulence, it is generally divided into three different strains, namely type I (RH strain), type II (PRU strain) and type III (VEG strain). Lysine malonylation (Kmal) is a new type of p...
ORGANISM(S): Toxoplasma gondii VEG 
2022-05-11 | PXD029366 | Pride
Toxoplasma gondii Differentially expressed proteins (deps) Lysine malonylation Genotype 
ProteomicsGlobal proteomic profiling of multiple organs of cat (Felis catus) and proteome-transcriptome correlation during acute Toxoplasma gondii infection
Understanding altered expression of proteins and transcripts associated with Toxoplasma gondii infection in cats may improve our understanding of how this parasite manipulates the molecular microenvironment of the definitive host. We performed proteomics analysis of six organs (brain, heart, spleen,...
ORGANISM(S): Felis catus (Cat) (Felis silvestris catus) 
2022-10-15 | PXD033778 | Pride
Toxoplasma gondii Toxoplasmosis Cat Correlation Proteomic profiling 
ProteomicsThe protein phosphatase 2A holoenzyme is a key regulator of starch metabolism and bradyzoite differentiation in Toxoplasma gondii
Phenotypic switching from tachyzoite to bradyzoite and vice versa is the fundamental mechanism underpinning the pathogenicity and adaptability of the protozoan parasite Toxoplasma gondii. Accumulation of cytoplasmic starch granules is a hallmark of the quiescent bradyzoite stage. The regulatory fact...
ORGANISM(S): Toxoplasma gondii 
2022-11-05 | PXD033120 | Pride
Pp2a holoenzyme Toxoplasma gondii Differentiation Dephosphorylation. Starch metabolism 
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