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ProteomicsGMPS promoting tumor immune evasion by regulating the glycosylation modification of PD-L1
Hepatocellular carcinoma (HCC) is a malignant tumor characterized by rapid progression, whose development is attributed to severe immune evasion. Here, we conducted proteomic and scRNA-Seq analysis on advanced HCC tissues and identified a significant molecule, Guanine monophosphate synthase (GMPS). ...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-25 | PXD045485 | Pride
Ptm Hcc Pd-l1 Immunotherapy 
UnknownFabrication of 3D Printed Polylactic Acid/Polycaprolactone Nanocomposites with Favorable Thermo-Responsive Cyclic Shape Memory Effects, and Crystallization and Mechanical Properties.
Not available
S-EPMC10053012 | biostudies-literature
UnknownMetabolome combined with transcriptome profiling reveals the dynamic changes in flavonoids in red and green leaves of Populus × euramericana 'Zhonghuahongye'.
Not available
S-EPMC10764563 | biostudies-literature
MetabolomicsMulti-omics analysis of Arabidopsis leaves upon infection by necrotrophic pathogen Botrytis cinerea

Botrytis cinerea is a necrotrophic pathogen that induces host cell death, causing substantial economic losses in agriculture. In this study, we show that functional depletion of INOSITOL AUXOTROPHY 80 (INO80), a nuclear factor involved in local chromatin remodeling, reduces the susceptibility of ...

2026-03-09 | MTBLS12467 | MetaboLights
UnknownEfficacy and safety of Hou Gu Mi Xi for peptic ulcer diseases: Study protocol for a randomized controlled trial.
Not available
S-EPMC6709288 | biostudies-literature
MetabolomicsIntegrated metagenomic and metabolomic analyses of the effects of total flavonoids of Rhizoma Drynariae on reducing ovariectomized-induced osteoporosis by regulating gut microbiota and related metabolites.

TFRD has been widely used in China to treat osteoporosis (OP). However, the specific molecular mechanism of TFRD against OP has not been fully clarified. Our previous studies have also proved that TFRD could attenuate OP and the clinical equivalent dose of 67.5 mg/kg/d is the effective dose for T...

2025-05-12 | MTBLS11866 | MetaboLights
TranscriptomicsAltered interactions between the gut microbiome and colonic mucosa precede polyposis in APCMin/+ mice
Mutation of the adenomatous polyposis coli (APC gene), an early event in the adenoma-carcinoma sequence, is present in 70-80% of sporadic human colorectal adenomas and carcinomas. To test the hypothesis that mutation of the APC gene alters microbial interactions with host intestinal mucosa prior to...
ORGANISM(S): Mus musculus 
2015-08-24 | E-GEOD-67634 | biostudies-arrayexpress
UnknownRapid detection of goose astrovirus genotypes 2 using real-time reverse transcription recombinase polymerase amplification.
Not available
S-EPMC10629041 | biostudies-literature
ProteomicsArabidopsis γ-H2A.X-INTERACTING PROTEIN participates in DNA damage response and safeguards chromatin stability
We extracted proteins from WT and xip for phospho-peptide enrichment and employed a quantitative phospho-proteomics approach to systematically survey the relevant modification changes.
ORGANISM(S): Arabidopsis Thaliana 
PXD037072 |
ProteomicsChemical Proteomics Profiling with an Indole Isocyanide Photoprobe
Chemoselective cysteine modification is pivotal for chemical biology and drug discovery. While photochemical strategies offer spatiotemporal control, most current methods rely on exogenous catalysts, complicating purification processes. Furthermore, the structural diversity of accessible conjugates ...
ORGANISM(S): Homo Sapiens 
2026-03-20 | PXD075923 |
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