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ProteomicsMurine colon HUNTER N-terminomics
The mammalian lysosomal protease legumain is often dysregulated in pathophysiological conditions including inflammation, neurodegeneration, and cancer, yet its proteolytic targets are poorly defined. To profile protease substrates degradomics techniques typically employ enrichment strategies to sele...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-29 | PXD060854 | Pride
Legumain Mouse Colon Colitis Hunter 
ProteomicsNaive and DSS Murine Colon TMTpro bRP fractionation N-terminomics
The mammalian lysosomal protease legumain is often dysregulated in pathophysiological conditions including inflammation, neurodegeneration, and cancer, yet its proteolytic targets are poorly defined. To profile protease substrates degradomics techniques typically employ enrichment strategies to sele...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-29 | PXD060852 | Pride
Mouse Protease Fractionation Legumain N-terminomics Colon Colitis 
ProteomicsFAIMS-enabled N-terminomics analysis reveals novel legumain substrates in murine spleen
Legumain is cysteine protease primarily localised to the endo-lysosomal system. Upregulated legumain activity is associated with inflammation, neurodegeneration, and tumorigenesis. Whilst inhibiting legumain in mouse models has demonstrated therapeutic benefit, the proteolytic mechanisms underpinnin...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD047733 | Pride
Faims Legumain Protease N-terminomics 
ProteomicsFAIMS-enabled N-terminomics analysis reveals novel legumain substrates in murine spleen
Legumain is cysteine protease primarily localised to the endo-lysosomal system. Upregulated legumain activity is associated with inflammation, neurodegeneration, and tumorigenesis. Whilst inhibiting legumain in mouse models has demonstrated therapeutic benefit, the proteolytic mechanisms underpinnin...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD047734 | Pride
Faims Legumain Protease N-terminomics 
UnknownIntegrative analysis of 111 reference human epigenomes.
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UnknownGuidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).
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S-EPMC7350392 | biostudies-literature
UnknownGuidelines for the use of flow cytometry and cell sorting in immunological studies.
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UnknownEfficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
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S-EPMC7787219 | biostudies-literature
UnknownGenetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
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S-EPMC4735748 | biostudies-literature
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