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ProteomicsAtLEGbeta / gamma protease specificity and putative substrate characterization by HUNTER
Arabidopsis thaliana Legumain (aka VPE) beta / gamma were characterized for their cleavage specificity and putative substrates were identified by the N-termini enrichment method HUNTER.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-07-29 | PXD019276 | Pride
Arabidopsis thaliana legumain vpe beta gamma protease hunter substrates 
ProteomicsOptimization of HUNTER N-termini profiling using rat brain proteome extracts
Optimization hydrophobic tagging reaction time (30 min to 2h) and evaluation of the HUNTER protocol performance with different amounts (25 ug to 400 ug) of purified rat brain proteome as starting material.
ORGANISM(S): Rattus norvegicus (Rat) 
2019-09-03 | PXD012844 | Pride
Wistar rat hunter n-termini 
GenomicsItalian Hunter-Gatherers
Genetic Insights into Italy's Epigravettian Hunter-Gatherers
PRJEB90269 | ENA
ProteomicsOptimization of HUNTER N-termini profiling using Arabidopsis thaliana Col-8 wt leaf proteome extracts
Optimization hydrophobic tagging reagent (hexadecanal or undecanal), reaction time (30 min to 16h) and evaluation of the HUNTER protocol performance with different amounts (25 ug to 400 ug) of purified Arabidopsis thaliana Col-8 wt leaf proteome as starting material.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-09-03 | PXD012821 | Pride
Hunter n-termini arabidopsis thaliana col-8 
ProteomicsMurine colon HUNTER N-terminomics
The mammalian lysosomal protease legumain is often dysregulated in pathophysiological conditions including inflammation, neurodegeneration, and cancer, yet its proteolytic targets are poorly defined. To profile protease substrates degradomics techniques typically employ enrichment strategies to sele...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-29 | PXD060854 | Pride
Legumain Mouse Colon Colitis Hunter 
GenomicsAcute Stress Induced Increase in Histone H3 Lys 9 Trimetylation in Rat Hippocampus
We utilized ChIP Seq to examine the the genomic localization of the increase in H3K9 trimethylation we had previously observed in the hippocampus as a consequence of acute restraint stress in rats (Hunter et. al PNAS 2009). Rats were restrained for 30 minutes, allowed to recover for 1 hour and then ...
ORGANISM(S): Rattus norvegicus 
2012-11-02 | E-GEOD-41217 | biostudies-arrayexpress
GenomicsThe demographic history and mutational load of African hunter-gatherers and farmers
The distribution of deleterious genetic variation across human populations is a key issue in evolutionary biology and medical genetics. However, the impact of different modes of subsistence on recent changes in population size, patterns of gene flow, and deleterious mutational load remains unclear. ...
EGAS00001002457 | EGA
GenomicsComplete Genomes of a Hunter-Gatherer and a Bantu from Southern Africa
The genetic structure of the indigenous hunter-gatherer peoples of Southern Africa, the oldest known lineage of modern man, holds an important key to understanding humanity's early history. Previously sequenced human genomes have been limited to recently diverged populations. Here we present the fir...
ORGANISM(S): Homo sapiens 
2010-02-18 | GSE19048 | GEO
ProteomicsHUNTER N-termini profiling of Arabidopsis thaliana leaves using different proteases
Comparison of protein N-termini in Arabidopsis thaliana leaves by the HUNTER method; the corresponding digestion was performed with legumain, GluC and trypsin.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-01-20 | PXD014697 | Pride
Arabidopsis hunter n-termini profiling 
TranscriptomicsNatural selection has contributed to functional immune response differences between human hunter-gatherers and agriculturalists
The shift from a hunter-gatherer (HG) to an agricultural (AG) mode of subsistence is believed to have been associated with profound changes in the burden and diversity of pathogens across human populations. Yet, the extent to which the advent of agriculture impacted the evolution of the human immune...
ORGANISM(S): Homo sapiens 
2018-09-27 | GSE120502 | GEO
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