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TranscriptomicsLongitudinal expression data from CD8+ T cells responding to LCMV-Armstrong or LCMV-Clone 13
During acute viral infections, naïve CD8+ T cells differentiate into effector CD8+ T cells and, after viral control, into memory CD8+ T cells. Memory CD8+ T cells are highly functional, proliferate rapidly upon reinfection and persist long-term without antigen. In contrast, during chronic infections...
ORGANISM(S): Mus musculus 
2012-11-23 | E-GEOD-41867 | biostudies-arrayexpress
ProteomicsPacked red blood cells inhibit T-cell activation via ROS-dependent signaling pathways
Numerous observations indicate that red blood cells (RBCs) affect T-cell activation and proliferation. We have studied effects of packed RBCs (PRBCs) on T-cell-receptor (TCR) signaling and the molecular mechanisms whereby (P)RBCs modulate T-cell activation. In line with previous reports, PRBCs atten...
ORGANISM(S): Homo sapiens (Human) 
2021-06-01 | PXD023144 | Pride
Reactive oxygen species (ros) T‐cell Erythrocyte Phosphoproteomics Immunosuppressor Redox regulation 
TranscriptomicsSingle-cell Atlas of intrahepatic T cells reveals a population of liver-resident naive-like CD4+ T cells expanded in primary sclerosing cholangitis
The composition of intrahepatic immune cells in primary sclerosing cholangitis (PSC) and their contribution to disease pathogenesis is widely unknown. We here generated a single-cell atlas of intrahepatic T cells in PSC, a type of immune cells that has previously been involved in the pathogenesis of...
ORGANISM(S): Homo sapiens 
2021-03-27 | E-MTAB-10143 | biostudies-arrayexpress
TranscriptomicsLoss of Foxp3-driven epigenetic modification leads to regulatory T cell insufficiency
Regulatory T cells (Tregs) are responsible for limiting autoimmunity and chronic inflammation. Foxp3 is a transcription factor that acts as a master regulator of Treg development and function. A serendipitous observation led to the realization that a well-characterized Foxp3gfp reporter mouse, whic...
ORGANISM(S): Mus musculus 
2012-12-07 | E-GEOD-35164 | biostudies-arrayexpress
ProteomicsThe proteomic landscape of patient-derived CD4+ T cells in recent-onset type 1 diabetes
The pathophysiology underlying the autoimmune disease type 1 diabetes (T1D) is poorly understood. Obtaining an accurate proteomic profile of the T helper cell population is essential for understanding the pathogenesis of T1D. Here, we performed in-depth proteomic profiling of peripheral CD4+ T cells...
ORGANISM(S): Homo sapiens (Human) 
2017-11-30 | PXD007184 | Pride
Data-independent Inflammation Neutrophil Cd4+ t cells Type 1 diabetes Biomarker Autoimmune Lc-ms/ms 
ProteomicsThe proteomic landscape of patient-derived CD4+ T cells in recent-onset type 1 diabetes
The pathophysiology underlying the autoimmune disease type 1 diabetes (T1D) is poorly understood. Obtaining an accurate proteomic profile of the T helper cell population is essential for understanding the pathogenesis of T1D. Here, we performed in-depth proteomic profiling of peripheral CD4+ T cells...
ORGANISM(S): Homo sapiens (Human) 
2017-11-30 | PXD006223 | Pride
Orbitrap xl Shotgun proteomics Cd4+ t-cells Human Lc-ms/ms dda Type 1 diabetes Autoimmune 
ProteomicsA Stat6/Pten axis links cold exposure with T cell tolerance in adipose tissue
Obesity and type-2 diabetes are associated with tissue-inflammation and metabolic defects in fat depots. Foxp3+regulatory T(Treg) cells mediate T-cell tolerance, thereby controlling tissue inflammation. However, the molecular underpinnings how environmental stimuli interlink T-cell tolerance with ad...
ORGANISM(S): Mus musculus (Mouse) 
2017-09-11 | PXD004671 | Pride
T cell tolerance Foxp3 Cold exposure 
TranscriptomicsWild-type p53 enhances efficiency of simian virus 40 large-T-antigen-induced cellular transformation
To measure on a global scale the SV40 large T antigen-mediated changes in gene transcription in mouse embryo fibroblasts differing in the expression of p53. Samples of total RNA from 3T3 (wt p53) and 10-1 (p53-null) mouse embryo fibroblasts stably transfected with SV40 large T-antigen expressing pMY...
ORGANISM(S): Mus musculus 
2009-07-18 | E-GEOD-17178 | biostudies-arrayexpress
ProteomicsImpact of de novo variants in the PSMC5 coding the AAA-ATPase proteasome subunit PSMC5/Rpt6 on the protein pattern of patient-derived primary T-cells in comparison to their wild-type counterparts.
To better understand the cellular consequences of mutations in the AAA-ATPase proteasome subunit PSMC5/Rpt6, we performed a mass spectrometry-based comparative analysis of the T-cell proteome of subjects with PSMC5 mutations to that of their wild-type counterparts.
ORGANISM(S): Homo sapiens (Human) 
2025-08-07 | PXD048558 | Pride
Protein homeostasis Psmc5 variants Proteasome Primary t-cells 
UnknownConformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell Selection.
Not available
S-EPMC7027375 | biostudies-literature
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