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TranscriptomicsTranscription profiling of hepatocyes from Zucker fa/fa obese rats vs controls
Analysis of the gene signature of steatosis associated to obesity in hepatocytes of Zucker fa/fa obese rats and their controls; identifying target genes linked to steatosis progression. or Obesity and insulin resistance-associated steatosis can be a non-inflammatory condition affecting hepatocytes o...
ORGANISM(S): Rattus norvegicus 
2008-07-31 | E-MEXP-1414 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of soleus muscle from lean and obese Zucker rats following exercise training
Endurance exercise training has been shown to decrease whole-body and skeletal muscle insulin resistance and increase glucose tolerance in conditions of both pre-diabetes and overt type 2 diabetes. However, the adaptive responses in skeletal muscle at the molecular and genetic level for these benef...
ORGANISM(S): Rattus norvegicus 
2009-11-16 | E-TABM-213 | biostudies-arrayexpress
ProteomicsiTRAQ-based quantitative comparison between lean and Zucker rat plasma proteins.
Study was conducted to investigate the differences in the expression of plasma proteins between lean and obese Zucker rats.
ORGANISM(S): Rattus norvegicus (Rat) 
2026-05-13 | PXD024178 | Pride
Zucker rat Lc-ms Plasma 
TranscriptomicsMolecular studies on sex-different control of the hepatic metabolism in relations to insulin sensitivity (set 2)
In this study we have analyzed gene expression and metabolite levels in the livers of male and female Zucker diabetic fatty (ZDF) rats. We speculated that the sex different development of diabetes in the ZDF animals presents the opportunity to relate gender to diabetes (since only males become diabe...
ORGANISM(S): Rattus norvegicus 
2011-08-09 | E-GEOD-23809 | biostudies-arrayexpress
TranscriptomicsMolecular studies on sex-different control of the hepatic metabolism in relations to insulin sensitivity (set 1)
In this study we have analyzed gene expression and metabolite levels in the livers of male and female Zucker diabetic fatty (ZDF) rats. We speculated that the sex different development of diabetes in the ZDF animals presents the opportunity to relate gender to diabetes (since only males become diabe...
ORGANISM(S): Rattus norvegicus 
2011-08-09 | E-GEOD-23808 | biostudies-arrayexpress
GenomicsRattus norvegicus breed:Zucker fa/fa
Zucker rat Metagenome
PRJNA380082 | ENA
TranscriptomicsMulti-tissue, selective PPARγ modulation of insulin sensitivity and metabolic pathways in obese rats
We characterized the insulin sensitivity and multi-tissue gene expression profiles of lean and insulin resistant, obese Zucker rats untreated or treated with one of four PPARγ ligands (pioglitazone, rosiglitazone, troglitazone, and AG035029). We analyzed the transcriptional profiles of adipose tissu...
ORGANISM(S): Rattus norvegicus 
2011-02-11 | E-GEOD-21329 | biostudies-arrayexpress
TranscriptomicsExpression data from rosiglitazone treated, rosiglitazone withdrawal and untreated control Zucker Diabetic Fatty rats.
Insulin resistance and islet failure are the two etiological roots of type 2 diabetes mellitus, and understanding global islet gene expression may provide insight into the mechanisms that regulate islet function. In this study we systematically investigated the gene expression profile and proliferat...
ORGANISM(S): Rattus norvegicus 
2013-06-21 | E-GEOD-30147 | biostudies-arrayexpress
ProteomicsMajor metabolic pathway alterations in the rat myocardium during development of Type 2 diabetes mellitus, part 2
The understanding of protein alterations in the diabetic heart is of vital importance because of increased risk of cardiovascular co-morbidities. The study aims at elucidating metabolic pathways in the diabetic rat heart during development of Type 2 diabetes mellitus using MS based proteomics.
ORGANISM(S): Rattus norvegicus (Rat) 
2018-06-26 | PXD009555 | Pride
Heart Type 2 diabetes mellitus Proteomics Mass spectrometry Lc-ms/ms Rattus 
UnknownC-Peptide-based assessment of insulin secretion in the Zucker Fatty rat: a modelistic study.
Not available
S-EPMC4418729 | biostudies-literature
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