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ProteomicsDIA MS analysis of primary breast cancers with no recurrence
We employed our recently developed proteogenomic workflow (De Marchi et al, 2021) to analyze a cohort of 21 primary breast cancers by RNA sequencing and mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2023-02-03 | PXD037428 | Pride
Dia Breast cancer 
ProteomicsValidation dataset on tamoxifen treated Estrogen Receptor (ER) positive breast cancer patients
56 Estrogen Receptor Positive Breast cancer tissues coming from patients treated with tamoxifen upon recurrence (41 Good outcome vs 15 Poor outcome) have been microdissected to enrich for breast cancer tumor cells. Enriched tissue has been lysed and proteins digested and analyzed in an LTQ-Orbitrap ...
ORGANISM(S): Homo sapiens (Human) 
2015-08-21 | PXD000485 | Pride
Mass spectrometry Estrogen receptor positive breast cancer Tamoxifen Metastasis 
ProteomicsDiscovery dataset on tamoxifen treated Estrogen Receptor (ER) positive breast cancer patients
56 estrogen receptor positive breast cancer tissues from patients treated with tamoxifen upon recurrence (32 Good outcome vs 24 Poor outcome) have been microdissected to obtain a pure population of epithelial tumor cells. Breast tumor enriched tissues have been sonicated and proteins have been in-so...
ORGANISM(S): Homo sapiens (Human) 
2015-08-21 | PXD000484 | Pride
Shotgun proteomics Estrogen receptor Breast cancer 
ProteomicsProteomic characterization of ESR1 mutant cells
Three quarters of all breast cancer cases express the estrogen receptor (ER, ESR1 gene), which promotes tumor growth and constitutes a direct target for endocrine therapies. ESR1 mutations have been implicated in therapy resistance in metastatic breast cancers, in particular to aromatase inhibitors....
ORGANISM(S): Homo sapiens (Human) 
2024-03-26 | PXD032369 | Pride
Esr1 mutation Breast cancer 
ProteomicsPhosphoproteome characterization of ESR1 mutated breast cancer cells
Three quarters of all breast cancer cases express the estrogen receptor (ER, ESR1 gene), which promotes tumor growth and constitutes a direct target for endocrine therapies. ESR1 mutations have been implicated in therapy resistance in metastatic breast cancers, in particular to aromatase inhibitors....
ORGANISM(S): Homo sapiens (Human) 
2024-03-26 | PXD032285 | Pride
Phosphoproteome Esr1 mutations Breast cancer 
ProteomicsInteractome of MSN mutations in leukemic cells
Characterization of the protein interactome of Moesin-mutated leukemia-initiating cells GPLM and pGM (as in Ugale et al., 2014).
ORGANISM(S): Mus musculus (Mouse) 
2022-05-19 | PXD028261 | Pride
Mouse 
ProteomicsCharacterization of U937 cells after SAHA treatment
U937 cells were treated with SAHA and DMSO. Proteome and phosphoproteome were measured by TMT10 LC-MS.
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD063064 | Pride
Phosphoproteome Human Proteome 
ProteomicsComparison between matched microdissected and whole tissue breast cancer specimen
A total of 38 flash-frozen breast cancer tissues were collected from three medical centers in the Netherlands (i.e. National Cancer institute: n=19; Radboud University Medical Center: n=4; Erasmus University Medical Center: n=15). All tissues were analyzed as laser capture microdissected (LCM) and w...
ORGANISM(S): Homo sapiens (Human) 
2016-03-31 | PXD002381 | Pride
Human Estrogen receptor positive breast cancer Lcm Whole tissue 
ProteomicsProteomic characterization of Prostate cancer cell lines
Proteomic characterization of prostate cancer cell lines after drug treatment.
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD029525 | Pride
Proteomics Mass spectrometry Label-free Prostate cancer 
ProteomicsDIA-MS analysis of 21 breast cancer tissues
In recent years genomic and proteomic technologies have been employed in a combined effort to extrapolate key clinical and biological information of complex diseases such as cancer. Most integrative studies employ DNA and/or RNA sequencing technologies coupled to mass spectrometry-derived informatio...
ORGANISM(S): Homo sapiens (Human) 
2021-04-26 | PXD018830 | Pride
Data independent acquisition Human Breast cancer Proteome 
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