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MetabolomicsGSDME-controlled pyroptosis promotes muscle repair by coordinating tissue resident macrophages and fibro-adipogenic progenitors
GSDME (Gasdermin E) is a critical protein known for its role in pyroptosis, a form of programmed cell death associated with inflammation. We demonstrated that GSDME as a crucial mediator in muscle repair, particularly in the context of muscle damage induced by cardiotoxin (CTX). Specifically, we fou...
2026-01-05 | MTBLS10509 | MetaboLights
ProteomicsRevealing disulfide bond formation in GSDME upon UVC irradiation under non-reducing conditions
It is widely acknowledged that gasdermin family proteins, which are known as the executors of pyroptosis, undergo protease-mediated cleavage prior to inducing pyroptosis. Here, we unexpectedly discovered a non-canonical form of pyroptosis mediated by full-length GSDME (FL-GSDME) without any proteoly...
ORGANISM(S): Homo sapiens (Human) 
2024-06-17 | PXD051840 | Pride
Uvc gsdme disulfide bond 
ProteomicsGasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1-mucin pathway
Pancreatic ductal adenocarcinoma (PDAC) originates from normal pancreatic ducts where digestive juice is regularly produced. It remains unclear how PDAC can escape auto-digestion by digestive enzymes. Here we show that human PDAC tumor cells use gasdermin E (GSDME), a pore-forming protein upon caspa...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030879 | Pride
Gsdme，pancreatic ductal adenocarcinoma，ybx1 Mucin 
ProteomicsIdentification of GSDME-interacting proteins in HK-2 cells by immunoprecipitation-coupled LC-MS/MS analysis
This project aims to identify GSDME-associated proteins in human renal tubular epithelial (HK-2) cells using immunoprecipitation followed by LC-MS/MS. HK-2 cells overexpressing Flag-tagged GSDME were lysed, and protein complexes were enriched using anti-Flag antibody and Protein A/G magnetic beads. ...
ORGANISM(S): Homo Sapiens 
2025-04-12 | PXD062902 |
GenomicsscRNA-seq of Abdominal aortic aneurysm tissues in Gsdme-KO mice
scRNA-seq of Abdominal aortic aneurysm tissues in Gsdme-KO mice
PRJNA1100918 | ENA
ProteomicsThe analysis of GSDME-NT binding proteins in the presence or absence of methionine
Our study identify that methionine inhibits N-terminus of GSDME (GSDME-NT) -mediated pyroptosis by dampening its endocytotic degradation. Thus，the binding proteins of GSDME-NT are detected in the presence or absence of Methionine for futher exploration。
ORGANISM(S): Homo Sapiens 
2025-01-19 | PXD059954 |
GenomicsGSDME-controlled pyroptosis promotes muscle repair by coordinating tissue resident macrophages and fibro-adipogenic progenitors
GSDME-controlled pyroptosis promotes muscle repair by coordinating tissue resident macrophages and fibro-adipogenic progenitors
PRJNA1127567 | ENA
GenomicsCASP10-mediated suppression of GSDME-dependent pyroptosis shapes the tumor immune microenvironment in hepatocellular carcinoma
CASP10-mediated suppression of GSDME-dependent pyroptosis shapes the tumor immune microenvironment in hepatocellular carcinoma
PRJNA1457315 | ENA
TranscriptomicsGSDME-controlled pyroptosis promotes muscle repair by coordinating tissue resident macrophages and fibro-adipogenic progenitors
GSDME (Gasdermin E) is a critical protein known for its role in pyroptosis, a form of programmed cell death associated with inflammation. We demonstrated that GSDME as a crucial mediator in muscle repair, particularly in the context of muscle damage induced by cardiotoxin (CTX). Specifically, we fou...
ORGANISM(S): Mus musculus 
2025-12-12 | GSE270614 | GEO
UnknownEndogenous HMGB1 regulates GSDME-mediated pyroptosis via ROS/ERK1/2/caspase-3/GSDME signaling in neuroblastoma
Not available
S-EPMC9989614 | biostudies-literature
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