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TranscriptomicsDistinct diversity of skin cell populations of rhinophyma and hypertrophic scar illustrated by scRNA-seq
The clinical manifestations and presentation of rhinophyma closely resemble those of hypertrophic scar tissue, both presenting as firm, fibrotic growths. Despite this phenotypic similarity, a critical divergence is observed following surgical intervention: the affected skin in rhinophyma can revert ...
ORGANISM(S): Homo sapiens 
2026-02-18 | E-MTAB-16629 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human hypertrophic scar fibroblast cell treated with fkbp10 siRNA against untreated controls
human hypertrophic scar fibroblast cell treated with fkbp10 siRNA and control siRNA for 48 hours
ORGANISM(S): Homo sapiens 
2020-08-26 | E-MTAB-9471 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human hypertrophic scar fibroblast cell treated with pcolce siRNA against untreated controls
human hypertrophic scar fibroblast cell treated with pcolce siRNA and control siRNA for 48 hours
ORGANISM(S): Homo sapiens 
2020-08-26 | E-MTAB-9472 | biostudies-arrayexpress
GenomicsEpigenome analysis of normal skin and hypertrophic scar samples
Epigenome analysis of normal skin and hypertrophic scar samples
PRJNA956447 | ENA
GenomicsPentoxifylline-induced differentially-expressed genes in hypertrophic scar fibroblasts
Pentoxifylline-induced differentially-expressed genes in hypertrophic scar fibroblasts
PRJNA506825 | ENA
GenomicsMicroarray profiling analysis of microRNAs expression in Hypertrophic scar
Microarray profiling analysis of microRNAs expression in Hypertrophic scar
PRJNA781618 | ENA
GenomicsSingle-cell analysis reveals transcriptomic difference between human hypertrophic scar and keloid
Single-cell analysis reveals transcriptomic difference between human hypertrophic scar and keloid
PRJNA1019688 | ENA
Methylation profilingEpigenome analysis of normal skin and hypertrophic scar samples
Hypertrophic scarring (HS) is characterized by excessive extracellular matrix deposition, matrix metalloprotein gene activation, and fibroblast invasive growth. However, the methylation level of hypertrophic scarring is poorly understood. Genome wide DNA methylation profiling of normal skin and hype...
ORGANISM(S): Homo sapiens 
2023-04-20 | GSE229848 | GEO
ProteomicsHigh-salt diet promotes hypertrophic scarring through TRPC3-mediated mitochondrial Ca2+ homeostasis dysfunction
Diet High in salt content have been associated with cardiovascular disease and chronic inflammation. We recently demonstrated that transient receptor potential canonical 3 (TRPC3) channels regulate myofibroblast transdifferentiation in hypertrophic scars. Here, we examined how high salt activation o...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD042087 | Pride
High salt hypertrophic scar trpc3 
GenomicsRNA-seq of human hypertrophic scar fibroblast cell treated with pcolce siRNA against untreated controls
RNA-seq of human hypertrophic scar fibroblast cell treated with pcolce siRNA against untreated controls
PRJEB39958 | ENA
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