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ProteomicsTissue-resident memory T cells maintain identity after in vitro restimulation
Resident memory T (TRM) cells have been recently established as an important subset of memory cells that provide early and essential protection against reinfection in the absence of circulating memory T cells. Recent findings showing that TRM expand in vivo after repeated antigenic stimulation indic...
ORGANISM(S): Mus musculus (Mouse) Listeria monocytogenes 
2025-09-30 | PXD041211 | Pride
Cd8+ memory t cells Tissue-resident memory t cells T cell metabolism Hypoxic t cell cultures 
ProteomicsG-CSFR expression is not essential for neutrophil differentiation but for progenitor formation and emergency neutrophil responses
Severe congenital neutropenia (SCN) is a rare disorder characterized by a maturation arrest of myeloid progenitor cells in the bone marrow and severe reduction in the amount of circulating neutrophils. Loss-of-function mutations in the CSF3R (the gene encoding the granulocyte colony-stimulating fact...
ORGANISM(S): Homo sapiens (Human) 
2020-09-25 | PXD018178 | Pride
Phagocytes Granulocytes And myelopoiesis 
ProteomicsMKL1 deficiency results in a neutrophil motility defect with impaired actin polymerization and excessive degranulation
Megakaryoblastic leukemia 1 (MKL1) promotes the regulation of essential cell processes, including actin cytoskeletal dynamics by co-activating serum response factor. Recently, the first human case with MKL1 deficiency has been identified, leading to a novel primary immunodeficiency. We report a seco...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD014633 | Pride
Mkl1 Actin poymerization Neutrophils Srf Mrtf-a 
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