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ProteomicsShotgun proteomics analysis of protein purifications from human plasma using antibodies and affimers
Antibodies are widely used to purify protein from complex mixtures like human plasma. Assessing the specificity of anntibodies, or any protein binder, is essential for the development of a protein biomarker assay. In addition to antibodies, novel protein binders like affimers are developed with a hi...
ORGANISM(S): Homo sapiens (Human) 
2020-05-29 | PXD016435 | Pride
Antibody Protein purification Affimer Lc-ms/ms 
ProteomicsPlasma glycoproteomics delivers high-specificity disease biomarkers by detecting site-specific glycosylation abnormalities
The human plasma glycoproteome holds enormous potential to identify personalized biomarkers to diagnose and understand disease. Recent advances in mass spectrometry and software development are opening novel avenues to mine the glycoproteome for protein- and site-specific glycosylation changes. Here...
ORGANISM(S): Homo sapiens (Human) 
2022-06-01 | PXD034214 | Pride
Glycoproteomics Plasma Glycopeptide Congenital disorders of glycosylation Blood 
ProteomicsTop-Down proteomics of unfractionated Bovine heart mitochondria
Top-Down proteomics pilot experiment of unfractionated Bovine Heart Mitochondria (BHM) using ultra high resolution Q-ToF tandem mass spectrometry (maXis 4G ETD, Bruker Daltonics).
ORGANISM(S): Bos taurus (Bovine) 
2018-04-05 | PXD005350 | Pride
Bovine Mitochondrion Protein Intact Top-down proteomics 
ProteomicsTargeted MRM assay Complement System in Health and Infectious Disease
The complement system is a central component of the innate immune system. Constitutive biosynthesis of complement proteins is essential for homeostasis. Dysregulation as a consequence of genetic or environmental cues can lead to inflammatory syndromes or increased susceptibility to infection. Howev...
ORGANISM(S): Homo Sapiens 
PXD014264 | panorama
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