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ProteomicsSyntaxin-3 is a Weibel-Palade body localized SNARE protein that regulates Von Willebrand factor secretion from endothelial cells
Endothelial cells store von Willebrand factor (VWF) in rod-shaped secretory organelles, called Weibel-Palade bodies (WPBs). WPB exocytosis is coordinated by a complex network of Rab GTPases, Rab-effectors and SNARE proteins. We have previously identified STXBP1 as the link between the Rab27A-Slp4-a ...
ORGANISM(S): Homo sapiens (Human) 
2018-07-04 | PXD006176 | Pride
Endothelial cells Proteomics Weibel-palade body Snare machinery Syntaxin-3 Von willebrand factor 
TranscriptomicsBlood DNA methylation profiles in a Dutch population
Genome wide DNA methylation profiling of whole blood in schizophrenia patients and healthy subjects of different ages. The Illumina Infinium 450k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 480,000 CpGs. Dataset included 62 schizophrenia patie...
ORGANISM(S): Homo sapiens 
2012-10-19 | E-GEOD-41169 | biostudies-arrayexpress
MetabolomicsNMR based metabolomics study of Y2 receptor activation by neuropeptide Y in the SK-N-BE2 human neuroblastoma cell line
Neuropeptide Y (NPY) and its Y2 receptors (Y2R) play an important role in regulating growth of various tumors and are highly expressed in human neuroblastoma brain tumors. Cell lines derived from neuroblastoma brain tumors provide a good model to study the consequences of NPY activation of Y2R in tu...
2014-10-01 | MTBLS104 | MetaboLights
TranscriptomicsLmrR Lactococcus lactis MG1363
Comparison of L. lactis NZ9000 ?lmrR versus L. lactis NZ9000 wild type Keywords: Transcription profiling Comparison between strain lacking transcriptional regulator LmrR of major Lactococcal mdr transporter LmrCD, and wild type parental strain.
ORGANISM(S): Lactococcus lactis subsp. cremoris MG1363 
2007-10-04 | E-GEOD-9168 | biostudies-arrayexpress
TranscriptomicsTemperature-dependent transcriptional response under anaerobic C and N limitations in Yeast
The global transcriptional response of Saccharomyces cerevisiae was investigated in low temperature chemostat cultures grown in carbon or nitrogen limitation. During steady state chemostats, the growth rates and in vivo fluxes were kept constant however the growth-limiting nutrient was significantly...
ORGANISM(S): Saccharomyces cerevisiae 
2007-01-20 | E-GEOD-6190 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML
Mononuclear cells from AML patients (n=46) were sorted into CD34+ and CD34- subfractions and genome-wide expression analysis was performed using Illumina BeadChip Arrays (HT12 v3). Of 2 AML samples only the CD34+ fraction could be analyzed. AML CD34+ and CD34- gene expression was compared to a large...
ORGANISM(S): Homo sapiens 
2011-07-18 | E-GEOD-30029 | biostudies-arrayexpress
TranscriptomicsAspergillus niger exposed to combinations of carbon source, nitrogen source, nitrogen concentration, and culture pH
Microarray analysis of Aspergillus niger under conditions with differing combinations of carbon source, nitrogen source, nitrogen concentration, and culture pH Fermentor cultures were grown in minimal medium (MM) at a constant temperature of 30 ± 0.5 ºC and with differing combinations of carbon sour...
ORGANISM(S): Aspergillus niger 
2010-04-08 | E-GEOD-17329 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae wild type and leu3 mutant strains in ethanol-limited and ammonium-limited conditions
Transcriptional regulation of branched-chain amino acid metabolism in Saccharomyces cerevisiae involves two key regulator proteins, Leu3p and Gcn4p. Leu3p is a pathway-specific regulator, known to regulate six genes involved in branched-chain amino acid metabolism and one gene in nitrogen assimilati...
ORGANISM(S): Saccharomyces cerevisiae 
2007-07-07 | E-GEOD-2076 | biostudies-arrayexpress
UnknownOuter-membrane translocation of bulky small molecules by passive diffusion.
Not available
S-EPMC4466742 | biostudies-literature
UnknownSphagnum mosses--masters of efficient N-uptake while avoiding intoxication.
Not available
S-EPMC3886977 | biostudies-literature
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