Dataset Information

Shared functional network abnormality in patients with temporal lobe epilepsy and their siblings.

ABSTRACT:

Aim

Temporal lobe epilepsy is a neurological network disease in which genetics played a greater role than previously appreciated. This study aimed to explore shared functional network abnormalities in patients with sporadic temporal lobe epilepsy and their unaffected siblings.

Methods

Fifty-eight patients with sporadic temporal lobe epilepsy, 13 unaffected siblings, and 30 healthy controls participated in this cross-sectional study. We examined the task-based whole-brain functional network topology and the effective functional connectivity between networks identified by group-independent component analysis.

Results

We observed increased global efficiency, decreased clustering coefficiency, and decreased small-worldness in patients and siblings (p < 0.05, false discovery rate-corrected). The effective network connectivity from the ventral attention network to the limbic system was impaired (p < 0.001, false discovery rate-corrected). These features had higher prevalence in unaffected siblings than in normal population and was not correlated with disease burden. In addition, topological abnormalities had a high intraclass correlation between patients and their siblings.

Conclusion

Patients with temporal lobe epilepsy and their unaffected siblings showed shared topological functional disturbance and the effective functional network connectivity impairment. These abnormalities may contribute to the pathogenesis that promotes the susceptibility of seizures and language decline in temporal lobe epilepsy.

SUBMITTER: Wang K

PROVIDER: S-EPMC10018100 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Publications

Shared functional network abnormality in patients with temporal lobe epilepsy and their siblings.

Wang Kangrun K Xie Fangfang F Liu Chaorong C Wang Ge G Zhang Min M He Jialinzi J Tan Langzi L Tang Haiyun H Chen Fenghua F Xiao Bo B Song Yanmin Y Long Lili L

CNS neuroscience & therapeutics 20230117 4

<h4>Aim</h4>Temporal lobe epilepsy is a neurological network disease in which genetics played a greater role than previously appreciated. This study aimed to explore shared functional network abnormalities in patients with sporadic temporal lobe epilepsy and their unaffected siblings.<h4>Methods</h4>Fifty-eight patients with sporadic temporal lobe epilepsy, 13 unaffected siblings, and 30 healthy controls participated in this cross-sectional study. We examined the task-based whole-brain functiona ...[more]

PMID: 36647843

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Dataset Information

Shared functional network abnormality in patients with temporal lobe epilepsy and their siblings.

Aim

Methods

Results

Conclusion

Publications

Shared functional network abnormality in patients with temporal lobe epilepsy and their siblings.

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