Shared functional network abnormality in patients with temporal lobe epilepsy and their siblings.

ABSTRACT:

Aim

Temporal lobe epilepsy is a neurological network disease in which genetics played a greater role than previously appreciated. This study aimed to explore shared functional network abnormalities in patients with sporadic temporal lobe epilepsy and their unaffected siblings.

Methods

Fifty-eight patients with sporadic temporal lobe epilepsy, 13 unaffected siblings, and 30 healthy controls participated in this cross-sectional study. We examined the task-based whole-brain functional network topology and the effective functional connectivity between networks identified by group-independent component analysis.

Results

We observed increased global efficiency, decreased clustering coefficiency, and decreased small-worldness in patients and siblings (p < 0.05, false discove

SUBMITTER: Wang K 

PROVIDER: S-EPMC10018100 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature