Coexistence of bla _KPC-IncFII plasmids and type I-E^* CRISPR-Cas systems in ST15 Klebsiella pneumoniae.

ABSTRACT: The CRISPR-Cas system in Klebsiella pneumoniae can prevent the entry of bla _KPC-IncF plasmids. However, some clinical isolates bear the KPC-2 plasmids despite carrying the CRISPR-Cas system. The purpose of this study was to characterize the molecular features of these isolates. A total of 697 clinical K. pneumoniae isolates were collected from 11 hospitals in China, and tested for the presence of CRISPR-Cas systems using polymerase chain reaction. Overall, 164 (23.5%) of 697 K. pneumoniae isolates had type I-E^* (15.9%) or type I-E (7.7%) CRISPR-Cas systems. The most prevalent sequence type among isolates carrying type I-E^* CRISPR was ST23 (45.9%), followed by ST15 (18.9%). Isolates with CRISPR-Cas system were more susceptible to

SUBMITTER: Hu Y 

PROVIDER: S-EPMC10030501 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature