Norepinephrine inhibits CD8⁺ T-cell infiltration and function, inducing anti-PD-1 mAb resistance in lung adenocarcinoma.

ABSTRACT:

Background

Mental stress-induced neurotransmitters can affect the immune system in various ways. Therefore, a better understanding of the role of neurotransmitters in the tumour immune microenvironment is expected to promote the development of novel anti-tumour therapies.

Methods

In this study, we analysed the plasma levels of neurotransmitters in anti-programmed cell death protein 1 (PD-1) monoclonal antibody (mAb)-resistance patients and sensitive patients, to identify significantly different neurotransmitters. Subsequently, animal experiments and experiments in vitro were used to reveal the specific mechanism of norepinephrine's (NE) effect on immunotherapy.

Results

The plasma NE levels were higher in anti-PD-1 mAb-resistance patients, which may be the main cause o

SUBMITTER: Geng Q 

PROVIDER: S-EPMC10050078 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature