Tonic extracellular glutamate and ischaemia: glutamate antiporter system x_c ^- regulates anoxic depolarization in hippocampus.

ABSTRACT: In stroke, the sudden deprivation of oxygen to neurons triggers a profuse release of glutamate that induces anoxic depolarization (AD) and leads to rapid cell death. Importantly, the latency of the glutamate-driven AD event largely dictates subsequent tissue damage. Although the contribution of synaptic glutamate during ischaemia is well-studied, the role of tonic (ambient) glutamate has received far less scrutiny. The majority of tonic, non-synaptic glutamate in the brain is governed by the cystine/glutamate antiporter, system x_c ^- . Employing hippocampal slice electrophysiology, we showed that transgenic mice lacking a functional system x_c ^- display longer latencies to AD and altered depolarizing waves compared to wild-type mice after total oxy

SUBMITTER: Heit BS 

PROVIDER: S-EPMC10107724 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature