Dataset Information

Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation.

ABSTRACT: Observational studies suggest that abnormal glucose metabolism and insulin resistance contribute to colorectal cancer; however, the causal association remains unknown, particularly in Asian populations. A two-sample Mendelian randomisation analysis was performed to determine the causal association between genetic variants associated with elevated fasting glucose, haemoglobin A1c (HbA1c), and fasting C-peptide and colorectal cancer risk. In the single nucleotide polymorphism (SNP)-exposure analysis, we meta-analysed study-level genome-wide associations of fasting glucose (~ 17,289 individuals), HbA1c (~ 52,802 individuals), and fasting C-peptide (1,666 individuals) levels from the Japanese Consortium of Genetic Epidemiology studies. The odds ratios of colorectal cancer were 1.01 (95% confidence interval [CI], 0.99-1.04, P = 0.34) for fasting glucose (per 1 mg/dL increment), 1.02 (95% CI, 0.60-1.73, P = 0.95) for HbA1c (per 1% increment), and 1.47 (95% CI, 0.97-2.24, P = 0.06) for fasting C-peptide (per 1 log increment). Sensitivity analyses, including Mendelian randomisation-Egger and weighted-median approaches, revealed no significant association between glycaemic characteristics and colorectal cancer (P > 0.20). In this study, genetically predicted glycaemic characteristics were not significantly related to colorectal cancer risk. The potential association between insulin resistance and colorectal cancer should be validated in further studies.

SUBMITTER: Hanyuda A

PROVIDER: S-EPMC10148817 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation.

Hanyuda Akiko A Goto Atsushi A Katagiri Ryoko R Koyanagi Yuriko N YN Nakatochi Masahiro M Sutoh Yoichi Y Nakano Shiori S Oze Isao I Ito Hidemi H Yamaji Taiki T Sawada Norie N Iwagami Masao M Kadota Aya A Koyama Teruhide T Katsuura-Kamano Sakurako S Ikezaki Hiroaki H Tanaka Keitaro K Takezaki Toshiro T Imoto Issei I Suzuki Midori M Momozawa Yukihide Y Takeuchi Kenji K Narita Akira A Hozawa Atsushi A Kinoshita Kengo K Shimizu Atsushi A Tanno Kozo K Matsuo Keitaro K Tsugane Shoichiro S Wakai Kenji K Sasaki Makoto M Yamamoto Masayuki M Iwasaki Motoki M

Scientific reports 20230429 1

Observational studies suggest that abnormal glucose metabolism and insulin resistance contribute to colorectal cancer; however, the causal association remains unknown, particularly in Asian populations. A two-sample Mendelian randomisation analysis was performed to determine the causal association between genetic variants associated with elevated fasting glucose, haemoglobin A1c (HbA1c), and fasting C-peptide and colorectal cancer risk. In the single nucleotide polymorphism (SNP)-exposure analys ...[more]

PMID: 37120602

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Dataset Information

Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation.

Publications

Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation.

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