Sleep and Breathing Disturbances in Children With Leigh Syndrome: A Comparative Study.

ABSTRACT:

Background

Leigh syndrome (LS) is a progressive neurodegenerative mitochondrial disease characterized by necrotizing lesions affecting different parts of the central nervous system, especially in the brainstem and basal ganglia. Lesions in this area may involve respiratory and sleep centers, resulting in the clinically significant disturbances seen-but poorly characterized-in LS. The purpose of the present study is to characterize and compare the physiologic responses to respiratory disturbances quantified by polysomnography metrics of children with LS with age-sex- and apnea-hypopnea index (AHI)-matched patients with obstructive sleep apnea (OSA), a common clinical population with similar burden of sleep-disordered breathing.

Methods

Retrospective comparative study of polys

SUBMITTER: Ju Wang JD 

PROVIDER: S-EPMC10243794 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature