Genetics of cannabis use in opioid use disorder: A genome-wide association and polygenic risk score study.

ABSTRACT:

Background

Individuals with an Opioid Use Disorder (OUD) have increased rates of cannabis use in comparison to the general population. Research on the short- and long-term impacts of cannabis use in OUD patients has been inconclusive. A genetic component may contribute to cannabis cravings.

Aims

Identify genetic variants associated with cannabis use through Genome-wide Association Study (GWAS) methods and investigate a Polygenic Risk Score (PRS). In addition, we aim to identify any sex differences in effect size for genetic variants reaching or nearing genome-wide significance in the GWAS.

Methods

The study outcomes of interest were: regular cannabis use (yes/no) (n = 2616), heaviness of cannabis use (n = 1293) and cannabis cravings (n = 836). Logistic and linear regr

SUBMITTER: Hillmer A 

PROVIDER: S-EPMC10370765 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature