Dataset Information

Potential causal association between aspirin use and the reduced risk of hayfever or allergic rhinitis: a Mendelian randomization study.

ABSTRACT:

Background

The evidence from observational studies on the association between the use of aspirin and the risk of hayfever or allergic rhinitis is conflicting, with a dearth of high-quality randomized controlled trials.

Objective

This study aims to investigate the causal relationship between aspirin use and the risk of hayfever or allergic rhinitis.

Methods

We conducted a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods. We utilized publicly available summary statistics datasets from genome-wide association studies (GWAS) meta-analyses on aspirin use in individuals of European descent (n = 337,159) as the exposure variable, and a GWAS on doctor-diagnosed hayfever or allergic rhinitis in individuals from the UK Biobank (n = 83,529) as the outcome variable.

Results

We identified 7 single nucleotide polymorphisms (SNPs) at genome-wide significance from the GWASs associated with aspirin use as instrumental variables (P<5×10-8; linkage disequilibrium r2 <0.1). The IVW method provided evidence supporting a causal association between aspirin use and reduced risk of hayfever or allergic rhinitis (β = -0.349, SE = 0.1356, P = 0.01008). MR-Egger regression indicated no causal association between aspirin use and hayfever or allergic rhinitis (β = -0.3742, SE = 0.3809, P = 0.371), but the weighted median approach yielded evidence of a causal association (β = -0.4155, SE = 0.1657, P = 0.01216). Cochran's Q test and the funnel plot indicated no evidence of heterogeneity and asymmetry, indicating no directional pleiotropy.

Conclusion

The findings of the MR analysis support a potential causal relationship between aspirin use and the reduced risk of hayfever or allergic rhinitis.

SUBMITTER: Li L

PROVIDER: S-EPMC10485696 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Publications

Potential causal association between aspirin use and the reduced risk of hayfever or allergic rhinitis: a Mendelian randomization study.

Li Li L Zhang Yuanding Y Liu Xiangliang X Li Junxin J Yang Qiuyu Q Jiang Jiajia J Liu Hong H Fu Zhongying Z Chen Weilun W

Frontiers in immunology 20230825

<h4>Background</h4>The evidence from observational studies on the association between the use of aspirin and the risk of hayfever or allergic rhinitis is conflicting, with a dearth of high-quality randomized controlled trials.<h4>Objective</h4>This study aims to investigate the causal relationship between aspirin use and the risk of hayfever or allergic rhinitis.<h4>Methods</h4>We conducted a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted med ...[more]

PMID: 37691954

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Dataset Information

Potential causal association between aspirin use and the reduced risk of hayfever or allergic rhinitis: a Mendelian randomization study.

Background

Objective

Methods

Results

Conclusion

Publications

Potential causal association between aspirin use and the reduced risk of hayfever or allergic rhinitis: a Mendelian randomization study.

Similar Datasets

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