Causal relationship between sarcopenia and osteoarthritis: a bi-directional two-sample mendelian randomized study.

ABSTRACT:

Background

Previous studies have shown that osteoarthritis (OA) and sarcopenia (SP) are closely related to each other, but the causal relationships between them have not been established. The aim of this study was to investigate the causal associations between OA and SP via a bi-directional Mendelian randomization (MR) approach.

Methods

A bi-directional two-sample MR was adopted to research the causal relationship between SP and OA. The instrumental variables for SP and four types of OA: KOA, HOA, total knee replacement (TKR) and total hip replacement (THR) were derived from published large genome-wide association studies (GWAS). The inverse variance weighted (IVW), MR-Egger and weighted median estimator (WME) methods were used to estimate bi-directional causal effects.

R

SUBMITTER: Yang J 

PROVIDER: S-EPMC10492359 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature