The association between educational attainment and SCA 3 age of onset and disease course.

ABSTRACT:

Background

The number of trinucleotide CAG repeats is inversely correlated with the age at onset (AAO) of motor symptoms in individuals with Spinocerebellar Ataxia type 3 (SCA 3) and may be responsible for 50%-60% of the variability in AAO. Drawing from a social determinants of health model, we sought to determine if educational attainment further contributes to the AAO and motor symptom progression of SCA 3.

Methods

We performed a retrospective chart review in which twenty individuals met criteria for inclusion and had been seen by an ataxia specialist at our hospital between January 2005 and July 2019. AAO of motor symptoms and Scale for Assessment and Rating of Ataxia (SARA) scores were used as primary outcome measures.

Results

Using a linear regression, we found t

SUBMITTER: Iannuzzelli K 

PROVIDER: S-EPMC10498785 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature