Evaluating the value of ¹⁸F-PSMA-1007 PET/CT in the detection and identification of prostate cancer using histopathology as the standard.

ABSTRACT:

Background

Prostate-specific membrane antigen (PSMA) PET/CT is a highly regarded radionuclide imaging modality for prostate cancer (PCa). This study aimed to evaluate the diagnostic performance of ¹⁸F-PSMA-1007 PET/CT in detecting intraprostatic lesions of PCa using radical prostatectomy (RP) specimens as a reference standard and to establish an optimal maximum standardized uptake value (SUVmax) cutoff for distinguishing between PCa and non-PCa lesions.

Methods

We retrospectively collected 117 patients who underwent ¹⁸F-PSMA-1007 PET/CT before RP. The uptake of the index tumor and contralateral non-PCa lesion was assessed. Histopathology of RP specimens was used as the gold standard. Kappa test was used to evaluate the consistency of preoperative PSMA P

SUBMITTER: Luo L 

PROVIDER: S-EPMC10623763 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature