Serum uric acid and risk of diabetic neuropathy: a genetic correlation and mendelian randomization study.

ABSTRACT:

Background

Previous observational studies have indicated an association between serum uric acid (SUA) and diabetic neuropathy (DN), but confounding factors and reverse causality have left the causality of this relationship uncertain.

Methods

Univariate Mendelian randomization (MR), multivariate MR and linkage disequilibrium score (LDSC) regression analysis were utilized to assess the causal link between SUA and DN. Summary-level data for SUA were drawn from the CKDGen consortium, comprising 288,648 individuals, while DN data were obtained from the FinnGen consortium, with 2,843 cases and 271,817 controls. Causal effects were estimated primarily using inverse variance weighted (IVW) analysis, supplemented by four validation methods, with additional sensitivity analyses to eva

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10684953 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature