A comprehensive two-sample Mendelian randomization analysis of trigeminal neuralgia and modifiable risk factors.

ABSTRACT:

Objective

To conduct a comprehensive search and causality study of potential modifiable risk factors for trigeminal neuralgia. To provide new ideas for subsequent treatment and management of patients with trigeminal neuralgia.

Methods

Data were obtained from large GWAS databases and then analyzed by Mendelian randomization analysis. The causal relationship between 36 potentially modifiable risk factors and trigeminal neuralgia was explored based on the results of the inverse variance weighting method(IVW). p < 0.05 was considered statistically significant.

Results

Years of schooling [OR (95%CI), 0.59(0.42-0.84), p = 0.003] to be a significant protective factor. Anxiety disorders [OR (95%CI), 1.62(1.05-2.48), p = 0.028], Depression [OR (95%CI), 1.5

SUBMITTER: Wei X 

PROVIDER: S-EPMC10703362 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature