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Ni-Catalyzed Stereoconvergent Reductive Dimerization of Bromocyclobutenes.

ABSTRACT: A nickel-catalyzed reductive dimerization of bromocyclobutenes to produce unusual and unprecedented cyclobutene dimers was developed. In a stereoconvergent procedure, various bromocyclobutenes were readily dimerized in good yields, with good diastereoselectivities and broad functional group tolerance. Notably, the presence of a carbonyl group in the starting material appears to dictate diastereoselectivity.

SUBMITTER: Spieß P

PROVIDER: S-EPMC10789092 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Ni-Catalyzed Stereoconvergent Reductive Dimerization of Bromocyclobutenes.

Spieß Philipp P Matheu Sergio Armentia SA Bauer Adriano A Coussanes Guilhem G Shaaban Saad S Maulide Nuno N

Organic letters 20231226 1

A nickel-catalyzed reductive dimerization of bromocyclobutenes to produce unusual and unprecedented cyclobutene dimers was developed. In a stereoconvergent procedure, various bromocyclobutenes were readily dimerized in good yields, with good diastereoselectivities and broad functional group tolerance. Notably, the presence of a carbonyl group in the starting material appears to dictate diastereoselectivity. ...[more]

PMID: 38147458

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