Molecular Diagnostics and [¹⁸F]FDG-PET/CT in Indeterminate Thyroid Nodules: Complementing Techniques or Waste of Valuable Resources?

ABSTRACT: Background: An accurate preoperative workup of cytologically indeterminate thyroid nodules (ITN) may rule out malignancy and avoid diagnostic surgery for benign nodules. This study assessed the performance of molecular diagnostics (MD) and 2-[¹⁸F]fluoro-2-deoxy-d-glucose ([¹⁸F]FDG)-positron emission tomography/computed tomography (PET/CT) in ITN, including their combined use, and explored whether molecular alterations drive the differences in [¹⁸F]FDG uptake among benign nodules. Methods: Adult, euthyroid patients with a Bethesda III or IV thyroid nodule were prospectively included in this multicenter study. They all underwent MD and an [¹⁸F]FDG-PET/CT scan of the neck. MD was performed using custom next-generation seq

SUBMITTER: de Koster EJ 

PROVIDER: S-EPMC10818054 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature