Quantitative classification and radiomics of [¹⁸F]FDG-PET/CT in indeterminate thyroid nodules.

ABSTRACT:

Purpose

To evaluate whether quantitative [¹⁸F]FDG-PET/CT assessment, including radiomic analysis of [¹⁸F]FDG-positive thyroid nodules, improved the preoperative differentiation of indeterminate thyroid nodules of non-Hürthle cell and Hürthle cell cytology.

Methods

Prospectively included patients with a Bethesda III or IV thyroid nodule underwent [¹⁸F]FDG-PET/CT imaging. Receiver operating characteristic (ROC) curve analysis was performed for standardised uptake values (SUV) and SUV-ratios, including assessment of SUV cut-offs at which a malignant/borderline neoplasm was reliably ruled out (≥ 95% sensitivity). [¹⁸F]FDG-positive scans were included in radiomic analysis. After segmentation at 50% of SUV_peak, 107 radiomic fe

SUBMITTER: de Koster EJ 

PROVIDER: S-EPMC9165273 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature