Therapeutic effects of long-term HBOT on Alzheimer's disease neuropathologies and cognitive impairment in APP^swe/PS1^dE9 mice.

ABSTRACT: Alzheimer's disease (AD) is the most common neurodegenerative disorder with the pathological hallmarks of amyloid beta (Aβ) plaques and neurofibrillary tangles (NFTs) in the brain. Although there is a hope that anti-amyloid monoclonal antibodies may emerge as a new therapy for AD, the high cost and side effect is a big concern. Non-drug therapy is attracting more attention and may provide a better resolution for the treatment of AD. Given the fact that hypoxia contributes to the pathogenesis of AD, hyperbaric oxygen therapy (HBOT) may be an effective intervention that can alleviate hypoxia and improve AD. However, it remains unclear whether long-term HBOT intervention in the early stage of AD can slow AD progression and ultimately prevent cognitive impairment in this disease. In this study

SUBMITTER: Yang C 

PROVIDER: S-EPMC10831255 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature