Association of asthma and lung cancer risk: A pool of cohort studies and Mendelian randomization analysis.

ABSTRACT:

Background

Over the past 2 decades, population-based studies have shown an increased association between asthma and the risk of lung cancer. However, the causal links between these 2 conditions remain poorly understood.

Methods

We conducted a comprehensive search of various databases, including PubMed, Embase, Web of Science, and Cochrane Library, up until May 04, 2023. Only articles published in English were included in our study. We performed a meta-analysis using random-effects models to calculate the odds ratio (OR) and corresponding 95% confidence interval (CI). Subgroup analyses were conducted based on study design, gender, and histologic types. We also conducted a 2-sample Mendelian randomization (MR) using the genome-wide association study pooled data (408,422 people

SUBMITTER: Huang Q 

PROVIDER: S-EPMC10843492 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature