Association of milk intake with hay fever, asthma, and lung function: a Mendelian randomization analysis.

ABSTRACT:

Background

Previous observational studies have indicated a protective effect of drinking milk on asthma and allergy. In Mendelian Randomization, one or more genetic variants are used as unbiased markers of exposure to examine causal effects. We examined the causal effect of milk intake on hay fever, asthma, forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) by using the lactase rs4988235 genotype associated with milk intake.

Methods

We performed a Mendelian Randomization study including 363,961 participants from the UK Biobank.

Results

Observational analyses showed that self-reported milk-drinkers vs. non-milk drinkers had an increased risk of hay fever: odds ratio (OR) = 1.36 (95% CI 1.32, 1.40, p < 0.001), asthma: OR = 1.33 (95% CI 1.38, 1

SUBMITTER: Skaaby T 

PROVIDER: S-EPMC7614013 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature