Association between circulating immune cells and the risk of prostate cancer: a Mendelian randomization study.

ABSTRACT:

Background

There is still limited research on the association between immune cells and the risk of prostate cancer. Further investigations are warranted to comprehend the intricate associations at play.

Methods

We used a bidirectional two-sample Mendelian randomization (MR) analysis to investigate the causal relationship between immune cell phenotypes and prostate cancer. The summary data for immune cell phenotypes was derived from a study cohort, including 3,757 individuals from Sardinia with data on 731 immune cell phenotypes. The summary data for prostate cancer were obtained from the UK Biobank database. Sensitivity analyses were conducted, and the combination of MR-Egger and MR-Presso was used to assess horizontal pleiotropy. Cochran's Q test was employed to evaluate he

SUBMITTER: Hao X 

PROVIDER: S-EPMC10884280 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature