Renal damage and old age: risk factors for thrombosis in patients with ANCA-associated vasculitis.

ABSTRACT:

Introduction

Thrombosis in ANCA-associated vasculitis (AAV) was prevalent and has been neglected in Chinese patients. This study tried to describe the clinical characteristics, identify the risk factors, and investigate the causal relationship between AAV and venous thromboembolism (VTE) by two-sample Mendelian randomization (MR) analysis.

Methods

In this retrospective, observational study, we included all hospitalized AAV patients from Jan 2013 to Apr 2022 in Peking Union Medical College Hospital. We collected their clinical data for multivariate regression analysis to determine the risk factors for thrombosis. The nomogram was constructed by applying these risk factors to predict thrombosis in AAV patients. As for MR analysis, we selected single nucleotide polymorphisms (S

SUBMITTER: Chen X 

PROVIDER: S-EPMC10953224 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature