Amino acids to prevent cardiac surgery-associated acute kidney injury: a randomized controlled trial.

ABSTRACT:

Background

This study aimed to examine the preventive effect of amino acids on postoperative acute kidney injury (AKI).

Methods

This was single-center, patient- and assessor-blinded, randomized controlled trial. Patients who underwent aortic surgery with cardiopulmonary bypass were included. The intervention group received 60 g/day of amino acids for up to 3 days. The control group received standard care. The primary outcome was the incidence of AKI. We assessed the effect of amino acids on AKI using a Cox proportional hazards regression model.

Results

Sixty-six patients were randomly assigned to the control or intervention group. One patient in the control group withdrew consent after randomization. The incidence of AKI was 10 patients (30.3%) in the intervention gro

SUBMITTER: Kazawa M 

PROVIDER: S-EPMC10963352 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature