Associations between gut microbiota and gynecological cancers: A bi-directional two-sample Mendelian randomization study.

ABSTRACT: Growing evidence has suggested that gut microbiota is associated with gynecologic cancers. However, whether there is a causal relationship between these associations remains to be determined. A two-sample Mendelian randomization (MR) evaluation was carried out to investigate the mechanism associating gut microbiota and 3 prevalent gynecological cancers, ovarian cancer (OC), endometrial cancer, and cervical cancer as well as their subtypes in individuals of European ancestry. The Genome-wide association studies statistics, which are publically accessible, were used. Eligible instrumental single nucleotide polymorphisms that were significantly related to the gut microbiota were selected. Multiple MR analysis approaches were carried out, including inverse variance weighted, MR-Egger, Weighted

SUBMITTER: Kong Y 

PROVIDER: S-EPMC10977594 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature