Systemic inflammatory regulators and preeclampsia: a two-sample bidirectional Mendelian randomization study.

ABSTRACT:

Background

Systemic inflammatory regulators have been associated with preeclampsia (PE) during pregnancy; however, there is inconsistent evidence from animal models and observational results.

Methods

Using summary data from genome-wide association studies (GWASs), we performed a bidirectional Mendelian randomization (MR) analysis of two samples of systemic inflammatory regulators (n = 8,186) and PE (n = 267,242) individuals of European ancestry. As our primary analysis, we used the random-effects inverse-variance weighted (IVW) approach. Sensitivity and pleiotropy analyses were conducted using the MR-Egger method, weighted median, MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO), and Cochran's Q test.

Results

The results indicate that there is a correl

SUBMITTER: Li C 

PROVIDER: S-EPMC10995280 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature