IL-27 maintains cytotoxic Ly6C⁺ γδ T cells that arise from immature precursors.

ABSTRACT: In mice, γδ-T lymphocytes that express the co-stimulatory molecule, CD27, are committed to the IFNγ-producing lineage during thymic development. In the periphery, these cells play a critical role in host defense and anti-tumor immunity. Unlike αβ-T cells that rely on MHC-presented peptides to drive their terminal differentiation, it is unclear whether MHC-unrestricted γδ-T cells undergo further functional maturation after exiting the thymus. Here, we provide evidence of phenotypic and functional diversity within peripheral IFNγ-producing γδ T cells. We found that CD27⁺ Ly6C^- cells convert into CD27⁺Ly6C⁺ cells, and these CD27⁺Ly6C⁺ cells control cancer progression in mice, while the CD27⁺Ly6C^- cells can

SUBMITTER: Wiesheu R 

PROVIDER: S-EPMC11251046 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature