New evidence that vitamin D prevents headache: a bidirectional two-sample Mendelian randomization analysis.

ABSTRACT:

Background

Previous observational clinical studies and meta-analyses have yielded inconsistent results regarding the relationship between vitamin D and headache, and the causal relationship remains unclear. The aim of this study was to investigate the causal relationship between vitamin D and headache by bidirectional two-sample Mendelian randomisation (MR) analysis.

Methods

The relationship between high levels of vitamin D and headache was investigated by two-sample MR analysis using publicly available genome-wide association study (GWAS) data. The primary method was inverse variance weighting (IVW), and secondary methods were weighted median and MR-Egger methods. No heterogeneity or horizontal multidirectionality was found in the MR results. The robustness and validity of

SUBMITTER: Xiong H 

PROVIDER: S-EPMC11310154 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature